Saori Akimoto
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Saori Akimoto has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Chikako Hara-Miyauchi
Tokyo Medical and Dental University
1 shared publication - Itsuki Ajioka
Center for Brain Integration Research (CBIR) Tokyo Medical and Dental University (TMDU) 1‐5‐45 Yushima Bunkyo‐ku Tokyo 113‐8510 Japan
1 shared publication Jumpei Kondo
Kyushu University
1 shared publicationMasanori Uji
Kyushu University
1 shared publication- Nobuhiro Yanai
The University of Tokyo
1 shared publication - Nobuo Kimizuka
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan
1 shared publication
Latest Publications
- Open Access
- 15 April 2024
- Published by American Chemical Society (ACS) in ChemRxiv
In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles
Photon upconversion (UC) from red or near-infrared (NIR) light to blue light is promising for in vivo optogenetics. However, the examples of in vivo optogenetics have been limited to lanthanide inorganic UC nanoparticles, and there have been no examples of optogenetics without using heavy metals. Here we show the first example of in vivo optogenetics using biocompatible heavy metal-free TTA-UC nanoemulsions. A new organic TADF sensitizer, a borondifluoride curcuminoid derivative modified with a bromo group, can promote intersystem crossing to the excited triplet state, significantly improving TTA-UC efficiency. The TTA-UC nanoparticles formed from biocompatible surfactants and methyl oleate acquire water dispersibility and remarkable oxygen tolerance. By combining with genome engineering technology using the blue light-responding photoactivatable Cre-recombinase (PA-Cre), TTA-UC nanoparticles promote Cre-reporter EGFP expression in neurons in vivo. Our results open new opportunities towards deep-tissue control of neural activities based on heavy metal-free fully organic UC systems.
- 15 April 2024
- Published by American Chemical Society (ACS) in ChemRxiv
Open AccessIn Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles
Photon upconversion (UC) from red or near-infrared (NIR) light to blue light is promising for in vivo optogenetics. However, the examples of in vivo optogenetics have been limited to lanthanide inorganic UC nanoparticles, and there have been no examples of optogenetics without using heavy metals. Here we show the first example of in vivo optogenetics using biocompatible heavy metal-free TTA-UC nanoemulsions. A new organic TADF sensitizer, a borondifluoride curcuminoid derivative modified with a bromo group, can promote intersystem crossing to the excited triplet state, significantly improving TTA-UC efficiency. The TTA-UC nanoparticles formed from biocompatible surfactants and methyl oleate acquire water dispersibility and remarkable oxygen tolerance. By combining with genome engineering technology using the blue light-responding photoactivatable Cre-recombinase (PA-Cre), TTA-UC nanoparticles promote Cre-reporter EGFP expression in neurons in vivo. Our results open new opportunities towards deep-tissue control of neural activities based on heavy metal-free fully organic UC systems.