Carolin Ecker
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Carolin Ecker has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Friederike Sophie Klockner
Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie, Universitätsmedizin Göttingen, Gottingen, Germany
2 shared publications - Katharina Jäckle
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany
2 shared publications - Lukas Weiser
University of Göttingen
2 shared publications - Marc-Pascal Meier
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University of Göttingen, Göttingen, Germany
2 shared publications - Maximilian Reinhold
University Medical Center Göttingen (UMG)
2 shared publications - Paul Jonathan Roch
University of Göttingen
2 shared publications
Latest Publications
- 1 July 2024
- Published by Springer Nature
- p. 1-10
Pancreas anulare und Pancreas divisum – embryonale Fehlbildungen des Pankreas
- 1 July 2024
- Published by Springer Nature
- p. 1-10
Pancreas anulare und Pancreas divisum – embryonale Fehlbildungen des Pankreas
- Open Access
- 13 June 2024
- Published by Springer Nature in Infection
- Vol. 52 (6) , 1
Correction: Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery
- 13 June 2024
- Published by Springer Nature in Infection
- Vol. 52 (6) , 1
Open AccessCorrection: Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery
- Open Access
- 6 May 2024
- Published by Springer Nature in Infection
- Vol. 52 (6) , 2269-2277
Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery
Purpose: Early diagnosis of surgical site infections (SSIs) could prevent surgical revision. Inflammatory markers (IMs), such as procalcitonin (PCT), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), seem more accurate in diagnosing SSI than C-reactive protein (CRP) and white blood cell (WBC) count. The aim was to compare the predictive values of CRP, WBC count, PCT, IL-6, and TNF-α in SSI detection. Methods: A total of 130 patients undergoing dorsal spondylodesis from 2019 to 2024 were enrolled in a prospective diagnostic study at a maximum care spine center. IMs were measured preoperatively and on the postoperative days (PODs) 1, 2, 3, 5, and 7. Patients with high suspicion of SSI underwent revision surgery. SSI was diagnosed when the microbiological evidence was positive. Patients were divided a posteriori into the non-infection and infection groups. Results: IMs of 118 patients (66.9 ± 13.0 years, 61.0% females) were measured. Fifteen of the 118 patients (12.7%) developed an SSI. The groups differed with respect to existing hypertension, number of instrumented segments, region of surgery, CRPPOD1,7, PCTPOD7, and IL-6POD3,5,7. Binary logistic regression for SSI detection including these parameters showed an area under the curve (AUC) of 0.88 (95% CI 0.79–0.98; P < 0.001). The main effect for SSI detection was maintained by IL-6POD7 (odds ratio = 1.13; 95% CI 1.05–1.23; P = 0.001), which itself showed an AUC of 0.86 (95% CI 0.75–0.97). Conclusion: Compared to CRP, WBC count, PCT, and TNF-α, IL-6 seems to be the critical IM for the early detection of an SSI. Trial registration: drks.de: DRKS00033773, date of registration: 29.02.2024, retrospectively registered; Postoperative Markers of Inflammation in Spine Surgery (POMIS) Trial.
- 6 May 2024
- Published by Springer Nature in Infection
- Vol. 52 (6) , 2269-2277
Open AccessInterleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery
Purpose: Early diagnosis of surgical site infections (SSIs) could prevent surgical revision. Inflammatory markers (IMs), such as procalcitonin (PCT), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), seem more accurate in diagnosing SSI than C-reactive protein (CRP) and white blood cell (WBC) count. The aim was to compare the predictive values of CRP, WBC count, PCT, IL-6, and TNF-α in SSI detection. Methods: A total of 130 patients undergoing dorsal spondylodesis from 2019 to 2024 were enrolled in a prospective diagnostic study at a maximum care spine center. IMs were measured preoperatively and on the postoperative days (PODs) 1, 2, 3, 5, and 7. Patients with high suspicion of SSI underwent revision surgery. SSI was diagnosed when the microbiological evidence was positive. Patients were divided a posteriori into the non-infection and infection groups. Results: IMs of 118 patients (66.9 ± 13.0 years, 61.0% females) were measured. Fifteen of the 118 patients (12.7%) developed an SSI. The groups differed with respect to existing hypertension, number of instrumented segments, region of surgery, CRPPOD1,7, PCTPOD7, and IL-6POD3,5,7. Binary logistic regression for SSI detection including these parameters showed an area under the curve (AUC) of 0.88 (95% CI 0.79–0.98; P < 0.001). The main effect for SSI detection was maintained by IL-6POD7 (odds ratio = 1.13; 95% CI 1.05–1.23; P = 0.001), which itself showed an AUC of 0.86 (95% CI 0.75–0.97). Conclusion: Compared to CRP, WBC count, PCT, and TNF-α, IL-6 seems to be the critical IM for the early detection of an SSI. Trial registration: drks.de: DRKS00033773, date of registration: 29.02.2024, retrospectively registered; Postoperative Markers of Inflammation in Spine Surgery (POMIS) Trial.