Anh Hoang Pham
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Anh Hoang Pham has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Chihiro Emori
Research Institute for Microbial Diseases, Osaka University , Osaka
1 shared publication - Keizo Tokuhiro
Department of Genome Editing, , , Osaka, Japan
1 shared publication - Maki Kamoshita
Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University Sagamihara Japan
1 shared publication - Masahito Ikawa
Department of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka
1 shared publication - Yoshitaka Fujihara
Department of Advanced Medical Technologies, National Cerebral and Cardiovascular Center
1 shared publication - Yu Ishikawa-Yamauchi
The University of Osaka
1 shared publication
Latest Publications
- Open Access
Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice
Infertility is considered a global health issue as it currently affects one in every six couples, with female factors reckoned to contribute to partly or solely 50% of all infertility cases. Over a thousand genes are predicted to be highly expressed in the female reproductive system and around 150 genes in the ovary. However, some of their functions in fertility remain to be elucidated. In this study, 13 ovary and/or oocyte-enriched genes (Ccdc58, D930020B18Rik, Elobl, Fbxw15, Oas1h, Nlrp2, Pramel34, Pramel47, Pkd1l2, Sting1, Tspan4, Tubal3, Zar1l) were individually knocked out by the CRISPR/Cas9 system. Mating tests showed that these 13 mutant mouse lines were capable of producing offspring. In addition, we observed the histology section of ovaries and performed in vitro fertilization in five mutant mouse lines. We found no significant anomalies in terms of ovarian development and fertilization ability. In this study, 13 different mutant mouse lines generated by CRISPR/Cas9 genome editing technology revealed that these 13 genes are individually not essential for female fertility in mice.
Open AccessThirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice
Infertility is considered a global health issue as it currently affects one in every six couples, with female factors reckoned to contribute to partly or solely 50% of all infertility cases. Over a thousand genes are predicted to be highly expressed in the female reproductive system and around 150 genes in the ovary. However, some of their functions in fertility remain to be elucidated. In this study, 13 ovary and/or oocyte-enriched genes (Ccdc58, D930020B18Rik, Elobl, Fbxw15, Oas1h, Nlrp2, Pramel34, Pramel47, Pkd1l2, Sting1, Tspan4, Tubal3, Zar1l) were individually knocked out by the CRISPR/Cas9 system. Mating tests showed that these 13 mutant mouse lines were capable of producing offspring. In addition, we observed the histology section of ovaries and performed in vitro fertilization in five mutant mouse lines. We found no significant anomalies in terms of ovarian development and fertilization ability. In this study, 13 different mutant mouse lines generated by CRISPR/Cas9 genome editing technology revealed that these 13 genes are individually not essential for female fertility in mice.