Liping Zhou
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Liping Zhou has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Juan Xin
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, China
1 shared publication - Lili Sun
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, China
1 shared publication - Qian Tang
School of Pharmacy, Chongqing Medical and Pharmaceutical College, 82 Middle College-City Road, Chongqing 401331, China
1 shared publication - Shanshan Li
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, China
1 shared publication - Wei Li
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, China
1 shared publication
Latest Publications
- Open Access
Facile Asymmetric Syntheses of Non-Natural Amino Acid (S)-Cyclopropylglycine by the Developed NADH-Driven Biocatalytic System
A self-sufficient bifunctional enzyme integrating reductive amination and coenzyme regeneration activities was developed and successfully employed to synthesize (S)-cyclopropylglycine with an improved reaction rate 2.1-fold over the native enzymes and a short bioconversion period of 6 h at a high substrate concentration of 120 g·L−1 and space–time yield of (S)-cyclopropylglycine up to 377.3 g·L−1·d−1, higher than that of any previously reported data. Additionally, (S)-cyclopropylglycine could be continuously synthesized for 90 h with the enzymes packed in a dialysis tube, providing 634.6 g of (S)-cyclopropylglycine with >99.5% ee and over 95% conversion yield up to 12 changes. These results confirmed that the newly developed NADH-driven biocatalytic system could be utilized as a self-sufficient biocatalyst for industrial application in the synthesis of (S)-cyclopropylglycine, which provides a chiral center and cyclopropyl fragment for the frequent synthesis of preclinical/clinical drug molecules.
Open AccessFacile Asymmetric Syntheses of Non-Natural Amino Acid (S)-Cyclopropylglycine by the Developed NADH-Driven Biocatalytic System
A self-sufficient bifunctional enzyme integrating reductive amination and coenzyme regeneration activities was developed and successfully employed to synthesize (S)-cyclopropylglycine with an improved reaction rate 2.1-fold over the native enzymes and a short bioconversion period of 6 h at a high substrate concentration of 120 g·L−1 and space–time yield of (S)-cyclopropylglycine up to 377.3 g·L−1·d−1, higher than that of any previously reported data. Additionally, (S)-cyclopropylglycine could be continuously synthesized for 90 h with the enzymes packed in a dialysis tube, providing 634.6 g of (S)-cyclopropylglycine with >99.5% ee and over 95% conversion yield up to 12 changes. These results confirmed that the newly developed NADH-driven biocatalytic system could be utilized as a self-sufficient biocatalyst for industrial application in the synthesis of (S)-cyclopropylglycine, which provides a chiral center and cyclopropyl fragment for the frequent synthesis of preclinical/clinical drug molecules.