Syed Bilal Nizami
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Syed Bilal Nizami has a total of 15 co-authors. Here are the top co-authors by number of shared publications:
- Alessia Corrado
University of Turin
1 shared publication - Allegra Conti
University of Rome Tor Vergata
1 shared publication - Danijela Gregurec
Biointerfaces Lab, Department of Chemistry and Pharmacy, Friedrich-Alexander Universität Erlangen-Nuremberg, Erlangen, Germany
1 shared publication - Elif Koçar
Friedrich-Alexander-Universität Erlangen-Nürnberg
1 shared publication - Enza Di Gregorio
University of Turin
1 shared publication - Franziska Wasner
Friedrich-Alexander-Universität Erlangen-Nürnberg
1 shared publication
Latest Publications
- Open Access
- 10 August 2025
- Published by American Chemical Society (ACS) in ChemRxiv
Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging
Magnetic nanodiscs (MNDs) represent a transformative class of anisotropic magnetic nanoparticles with intrinsic vortex magnetization, enabling multifunctional applications in biomedical imaging and therapy. Here, we demonstrate their potential as dual-mode magnetic resonance (MR) contrast agents, a unique feature that is enabled by the high longitudinal relaxivity (r₁ ≈ 40 mM⁻¹s⁻¹) at ultralow magnetic fields ( 150 mM⁻¹s⁻¹) at ultrahigh fields (>7 T). This field-dependent relaxivity profile uniquely positions MNDs as versatile T₁/T₂ agents compatible with emerging low-field MRI platforms and high-resolution clinical systems. Ex vivo and in vivo assessments confirmed clear anatomical localization and preferential hepatic accumulation, suggesting prolonged circulation times due to surface-mediated immune evasion. These properties highlight MNDs as promising candidates for next-generation theranostics, with tunable magnetic responses, high contrast efficiency, and the ability to synergize imaging and neurostimulation.
- 10 August 2025
- Published by American Chemical Society (ACS) in ChemRxiv
Open AccessMagnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging
Magnetic nanodiscs (MNDs) represent a transformative class of anisotropic magnetic nanoparticles with intrinsic vortex magnetization, enabling multifunctional applications in biomedical imaging and therapy. Here, we demonstrate their potential as dual-mode magnetic resonance (MR) contrast agents, a unique feature that is enabled by the high longitudinal relaxivity (r₁ ≈ 40 mM⁻¹s⁻¹) at ultralow magnetic fields ( 150 mM⁻¹s⁻¹) at ultrahigh fields (>7 T). This field-dependent relaxivity profile uniquely positions MNDs as versatile T₁/T₂ agents compatible with emerging low-field MRI platforms and high-resolution clinical systems. Ex vivo and in vivo assessments confirmed clear anatomical localization and preferential hepatic accumulation, suggesting prolonged circulation times due to surface-mediated immune evasion. These properties highlight MNDs as promising candidates for next-generation theranostics, with tunable magnetic responses, high contrast efficiency, and the ability to synergize imaging and neurostimulation.