Mikaela dos Santos Marinho
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Mikaela dos Santos Marinho has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Ana Carolina Gomes Jardim
Laboratory of Antiviral Research (LAPAV), Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Brazil
1 shared publication - Giulia Magalhães Ferreira
Laboratório de Virologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlandia, Brazil
1 shared publication - Igor Andrade Santos
Viral Glycoproteins Group, The Pirbright Institute, Pirbright, Woking, UK
1 shared publication - Nilson Nicolau-Junior
Laboratory of Molecular Modeling, Institute of Biotechnology, Federal University of Uberlandia, Uberlândia 38400-902, MG, Brazil
1 shared publication - Túlio de Lima Campos
Bioinformatics Center, Aggeu Magalhães Institute, Oswaldo Cruz Foundation Recife Pernambuco Brazil
1 shared publication - Victória Riquena Grosche
Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, São Paulo, Brazil
1 shared publication
Latest Publications
- Open Access
Evolutionary Profile of Mayaro Virus in the Americas: An Update into Genome Variability
The Mayaro virus (MAYV) is an arbovirus with emerging potential, though with a limited understanding of its epidemiology and evolution due to the lack of studies and surveillance. Here, we investigated 71 MAYV genome sequences from the Americas available at GenBank and characterized the phylogenetic relationship among virus strains. A phylogenetic analysis showed that sequences were grouped according to the genotypes L, D, and N. Genotype D sequences were closely related to sequences collected in adjacent years and from their respective countries, suggesting that isolates may have originated from circulating lineages. The coalescent analysis demonstrated similar results, indicating the continuous circulation of the virus between countries as well. An unidentified sequence from the USA was grouped with genotype D, suggesting the insertion of this genotype in the country. Furthermore, the recombination analysis detected homologous and three heterologous hybrids which presented an insertion into the nsP3 protein. Amino acid substitutions among sequences indicated selective pressure sites, suggesting viral adaptability. This also impacted the binding affinity between the E1–E2 protein complex and the Mxra8 receptor, associated with MAYV entry into human cells. These results provide information for a better understanding of genotypes circulating in the Americas.
Open AccessEvolutionary Profile of Mayaro Virus in the Americas: An Update into Genome Variability
The Mayaro virus (MAYV) is an arbovirus with emerging potential, though with a limited understanding of its epidemiology and evolution due to the lack of studies and surveillance. Here, we investigated 71 MAYV genome sequences from the Americas available at GenBank and characterized the phylogenetic relationship among virus strains. A phylogenetic analysis showed that sequences were grouped according to the genotypes L, D, and N. Genotype D sequences were closely related to sequences collected in adjacent years and from their respective countries, suggesting that isolates may have originated from circulating lineages. The coalescent analysis demonstrated similar results, indicating the continuous circulation of the virus between countries as well. An unidentified sequence from the USA was grouped with genotype D, suggesting the insertion of this genotype in the country. Furthermore, the recombination analysis detected homologous and three heterologous hybrids which presented an insertion into the nsP3 protein. Amino acid substitutions among sequences indicated selective pressure sites, suggesting viral adaptability. This also impacted the binding affinity between the E1–E2 protein complex and the Mxra8 receptor, associated with MAYV entry into human cells. These results provide information for a better understanding of genotypes circulating in the Americas.