Zhi-Jun Huang
Zhi-Jun Huang has a total of 28 co-authors. Here are the top co-authors by number of shared publications:
- Gang Zhao
Institute of Pharmaceutical Research, Jianmin Pharmaceutical Group Co., LTD, Hubei 430050, P. R. China
3 shared publications - Huafang Chen
The First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, P. R. China
3 shared publications - Huizhen Li
Department of Gastroenterology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, P.R China
2 shared publications - Yun-Lian Hu
Hubei Provincial Traditional Chinese Medicine Hospital 430070, P. R. China
2 shared publications - Baoqing Zhang
Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 16369 Jingshi Road, Jinan, 250014, China
1 shared publication - Bin Yu
The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Hunan,423399, P. R. China
1 shared publication
Latest Publications
- Open Access
- 8 May 2026
- Published by MDPI AG in Preprints.org
Medicinal Plant-Derived Exosome-Like Nanoparticles: From Basic Research to Biomedical Applications
Plant-derived exosome-like nanoparticles (PELNs), a subset of extracellular vesicle (EV) secreted by plant cells, have emerged as revolutionary biomaterial with broad applications in biomedicine, agriculture, and nanotechnology. Structurally, PELNs feature with phospholipid bilayer homologous to plant cell membranes, encapsulating bioactive components such as proteins, nucleic acids, lipids, and secondary metabolites. The native structure of PELNs endows them with enhanced bioavailability, reduced immunogenicity, and improved barrier penetration for precise tissue delivery. Recent researches highlight the cross-kingdom therapeutic potential of PELNs in mammals, including antitumor, anti-inflammatory, tissue repair, immunomodulation and so on. This review comprehensively summarized recent advancements in PELNs researches, including innovative isolation techniques, molecular characterization, their roles in drug delivery and disease therapy. We also discussed challenges in standardization, scalability, and regulatory frameworks which could provide future perspectives for translating PELNs into clinical and industrial applications.
- 8 May 2026
- Published by MDPI AG in Preprints.org
Open AccessMedicinal Plant-Derived Exosome-Like Nanoparticles: From Basic Research to Biomedical Applications
Plant-derived exosome-like nanoparticles (PELNs), a subset of extracellular vesicle (EV) secreted by plant cells, have emerged as revolutionary biomaterial with broad applications in biomedicine, agriculture, and nanotechnology. Structurally, PELNs feature with phospholipid bilayer homologous to plant cell membranes, encapsulating bioactive components such as proteins, nucleic acids, lipids, and secondary metabolites. The native structure of PELNs endows them with enhanced bioavailability, reduced immunogenicity, and improved barrier penetration for precise tissue delivery. Recent researches highlight the cross-kingdom therapeutic potential of PELNs in mammals, including antitumor, anti-inflammatory, tissue repair, immunomodulation and so on. This review comprehensively summarized recent advancements in PELNs researches, including innovative isolation techniques, molecular characterization, their roles in drug delivery and disease therapy. We also discussed challenges in standardization, scalability, and regulatory frameworks which could provide future perspectives for translating PELNs into clinical and industrial applications.