Georg Falck
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Georg Falck has a total of 1 co-authors. Here are the top co-authors by number of shared publications:
- Kristian Mark Müller
Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, Bielefeld, Germany
1 shared publication
Latest Publications
- Open Access
- 4 January 2018
- Published by MDPI AG in Antibodies
- Vol. 7 (1) , 4
Enzyme-Based Labeling Strategies for Antibody–Drug Conjugates and Antibody Mimetics
Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for therapeutic or diagnostic applications. The recent quest for next-generation antibody–drug conjugates (ADCs) sparked research into techniques with site selectivity. While purely chemical approaches often impede control of dosage or locus of derivatization, naturally occurring enzymes and proteins bear the ability of co- or post-translational protein modifications at particular residues, thus enabling unique coupling reactions or protein fusions. This review provides a general overview and focuses on chemo-enzymatic methods including enzymes such as formylglycine-generating enzyme, sortase, and transglutaminase. Applications for the conjugation of antibodies and antibody mimetics are reported.
- 4 January 2018
- Published by MDPI AG in Antibodies
- Vol. 7 (1) , 4
Open AccessEnzyme-Based Labeling Strategies for Antibody–Drug Conjugates and Antibody Mimetics
Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for therapeutic or diagnostic applications. The recent quest for next-generation antibody–drug conjugates (ADCs) sparked research into techniques with site selectivity. While purely chemical approaches often impede control of dosage or locus of derivatization, naturally occurring enzymes and proteins bear the ability of co- or post-translational protein modifications at particular residues, thus enabling unique coupling reactions or protein fusions. This review provides a general overview and focuses on chemo-enzymatic methods including enzymes such as formylglycine-generating enzyme, sortase, and transglutaminase. Applications for the conjugation of antibodies and antibody mimetics are reported.