R. Öhrlein
Research Subjects
Research Interests
R. Öhrlein has a total of 1 co-authors. Here are the top co-authors by number of shared publications:
Gabriele Baisch
CIBA SC group research, 4002 Basel, Switzerland Fax: (+41)-616364011
1 shared publication
Latest Publications
- 3 June 2003
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 345 (6-7) , 713-715
Chemo‐Enzymatic Approach to Statin Side‐Chain Building Blocks
A versatile statin side‐chain building block is obtained by an enzymatic desymmetrisation of the symmetrical glutaric acid diethyl ester. The monoacid is produced in almost quantitative yield in the desired high optical purity. The monoacid is easily converted to the corresponding acid chloride, which is a key compound to be elaborated to some statin side‐chain derivatives. The optically active C‐5 chain is subsequently elongated by two carbon atoms and syn‐reduced to the final diol fragment.
- 3 June 2003
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 345 (6-7) , 713-715
Chemo‐Enzymatic Approach to Statin Side‐Chain Building Blocks
A versatile statin side‐chain building block is obtained by an enzymatic desymmetrisation of the symmetrical glutaric acid diethyl ester. The monoacid is produced in almost quantitative yield in the desired high optical purity. The monoacid is easily converted to the corresponding acid chloride, which is a key compound to be elaborated to some statin side‐chain derivatives. The optically active C‐5 chain is subsequently elongated by two carbon atoms and syn‐reduced to the final diol fragment.