Thomas Bruun Rasmussen
Research Subjects
Research Interests
Thomas Bruun Rasmussen has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
Ilona Reimann
Institute of Molecular Biology, Friedrich-Loeffler-Institut, Boddenblick 5a, D-17493 Greifswald-Insel Riems, Germany
1 shared publicationJens Nielsen
Department of Virology, Danish Institute for Food and Veterinary Research, Lindholm, DK-4771 Kalvehave, Denmark
1 shared publicationKlaus Depner
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Boddenblick 5a, D-17493 Greifswald-Insel Riems, Germany
1 shared publicationMartin Beer
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Boddenblick 5a, D-17493 Greifswald-Insel Riems, Germany
1 shared publicationÅse Uttenthal
Department of Virology, Danish Institute for Food and Veterinary Research, Lindholm, DK-4771 Kalvehave, Denmark
1 shared publication
Latest Publications
- 1 February 2007
- Published by Microbiology Society in Journal of General Virology
- Vol. 88 (2) , 481-486
Virulence, immunogenicity and vaccine properties of a novel chimeric pestivirus
A chimeric pestivirus of border disease virus Gifhorn and bovine viral diarrhea virus CP7 ( Meyers et al., 1996 ) was constructed. Virulence, immunogenicity and vaccine properties of the chimeric virus were studied in a vaccination–challenge experiment in pigs. The chimeric virus proved to be avirulent and neither chimeric virus nor viral RNA was detected in serum after vaccination. The safety of the vaccine was tested by horizontal transmission to sentinel pigs, which remained uninfected. The vaccine efficacy was examined by challenge infection with classical swine fever virus (CSFV) Eystrup. In ‘challenge controls’, the viral load of CSFV coincided with the development of pronounced clinical symptoms. In contrast, the vaccinated pigs showed transient and weak clinical signs. Analysis of the viral load in these pigs showed 1000-fold lower viral RNA levels compared to ‘challenge controls' and horizontal transmission of challenge virus to sentinel pigs was not observed.
- 1 February 2007
- Published by Microbiology Society in Journal of General Virology
- Vol. 88 (2) , 481-486
Virulence, immunogenicity and vaccine properties of a novel chimeric pestivirus
A chimeric pestivirus of border disease virus Gifhorn and bovine viral diarrhea virus CP7 ( Meyers et al., 1996 ) was constructed. Virulence, immunogenicity and vaccine properties of the chimeric virus were studied in a vaccination–challenge experiment in pigs. The chimeric virus proved to be avirulent and neither chimeric virus nor viral RNA was detected in serum after vaccination. The safety of the vaccine was tested by horizontal transmission to sentinel pigs, which remained uninfected. The vaccine efficacy was examined by challenge infection with classical swine fever virus (CSFV) Eystrup. In ‘challenge controls’, the viral load of CSFV coincided with the development of pronounced clinical symptoms. In contrast, the vaccinated pigs showed transient and weak clinical signs. Analysis of the viral load in these pigs showed 1000-fold lower viral RNA levels compared to ‘challenge controls' and horizontal transmission of challenge virus to sentinel pigs was not observed.