David Weinkove
Research Subjects
Research Interests
David Weinkove has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Carlos de Lecea
AB Biotek Human Nutrition and Health, 08017 Barcelona, Spain
1 shared publication - Collin Y. Ewald
Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology ETH Zürich Schwerzenbach Switzerland
1 shared publication - Elisabeth Jongsma
Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland
1 shared publication - Franziska Wandrey
Mibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland
1 shared publication - Giovanna Grigolon
Mibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland
1 shared publication Jordi Cuñé
AB Biotek Human Nutrition and Health, Peterborough, PE7 8QJ, UK
1 shared publication
Latest Publications
- Open Access
- 5 August 2024
- Published by Elsevier in PharmaNutrition
- Vol. 29
Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans
- 5 August 2024
- Published by Elsevier in PharmaNutrition
- Vol. 29
Open AccessCombinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans
- Open Access
Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians’ diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism Caenorhabditis elegans. We show that Timut pepper extract extends C. elegans’ lifespan at different maintenance temperatures and increases the proportion of active nematodes in their early adulthood. In addition, we show that Timut pepper extract enhances speed and distance moved as the nematodes age. Finally, Timut pepper extract assures extracellular matrix homeostasis by slowing the age-dependent decline of collagen expression.
Open AccessTimut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians’ diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism Caenorhabditis elegans. We show that Timut pepper extract extends C. elegans’ lifespan at different maintenance temperatures and increases the proportion of active nematodes in their early adulthood. In addition, we show that Timut pepper extract enhances speed and distance moved as the nematodes age. Finally, Timut pepper extract assures extracellular matrix homeostasis by slowing the age-dependent decline of collagen expression.