Judite Salência-Ferrão

Even with a great reduction in the last years, diarrhoea continues to be one of the leading causes of hospital admission and mortality in children less than five years of age globally. The success of diarrhoeal disease management relies on the rapid recognition of the symptoms and adequate treatment, with World Health Organization (WHO) guidelines, limiting the use of antibiotics for all diarrhoea cases being reserved to specific circumstances. Therefore, this study aimed to evaluate the frequency of antibiotics use in diarrhoea management in children aged 0–59 months admitted with acute diarrhoea in four provinces of Mozambique, from 2014 to 2019. A cross-sectional hospital-based surveillance was conducted from January 2014 to December 2019 in six sentinel sites located in four provinces. Socio-demographic, epidemiological and clinical data were obtained by interviewing the child’s caregivers and by accessing the child’s medical records and children’s vaccination card. Data collected through National Surveillance of Diarrhoea (ViNaDia) was double-entered in Epi InfoTM3.5.1. (Centers for Disease Control and Prevention, Atlanta 2008), followed by data comparison. IBM SPSS software was used to conduct the data analysis. During the study period 2014–2019 a total of 2382 children presenting at one of the designated health facilities were enrolled via ViNaDia surveillance. Of these 85.1% (2028/2382) provided data of antibiotics (ATB) usage and thus included in the present analysis. The majority was male with 59.3% (1203/2028), with infants aged 0–11 months composing the largest age group with 49.4% (1002/2028). Nutritional assessment revealed that 28.8% (585/2028) were underweight and 15.2% (308/2028) faced wasting. The comorbidities included human immunodeficiency virus (HIV) 7.8% (159/2028), malaria 7.0% (141/2028), and pneumonia 2.1% (42/2028). The rates of bloody diarrhoea and “rice-water” were reported in 1.5% (10/1664) and 2% (29/1664) respectively. Antibiotics use was reported in 93.2% of the children [95% CI: 92.0–94.2; 1890/2028], with s 49.1% [95% CI: 47.0–51.5; 930/1890] received more than one ATB. The most prescribed antibiotics were Ampicillin (46.2%), Gentamicin (38.4%) and Cotrimoxazole (30.5%). The results of this study indicate inappropriate use of antibiotics in the management of acute diarrhoea in children attended in four provinces of Mozambique. The study suggests the drawing of a local guideline for the efficient management of acute diarrhoea, and the need for education on adherence of WHO recommendations on antibiotics use in acute diarrhoea.

The epidemiology and characteristics of SARS-CoV-2 in the hospitalized Mozambican pediatric population are scarce. We aimed to assess the burden of COVID-19 in the pediatric population at Hospital Central de Maputo and identify comorbidities and factors associated with death among hospitalized COVID-19 cases. A cross-sectional study was conducted from October 2020 to October 2022. Available records were retrieved from admission books. Univariate and bivariate analyses were reported to describe the sample characteristics. The frequency of pediatric cases admitted with COVID-19 was 0.6% (95% confidence interval (CI): 0.5–0.6; 364/63,753), and the frequency of pediatric cases hospitalized with COVID-19 was 2.5% (95% CI: 2.2–2.9; 173/6807). The monthly frequency of pediatric cases admitted and hospitalized with COVID-19 ranged from 0.1% to 5.4% and from 0.2% to 42.1%, respectively. In children hospitalized with COVID-19, underweight was the most observed comorbidity (17.4%; 19/109); death was observed in 30% (95% CI: 22.2–39.1; 33/110), and it was significantly higher in underweight children than in non-underweight children (61.5% [8/13] vs. 21.3% [16/75]; p-value = 0.005). Given the heightened risk of mortality among undernourished children compared to non-undernourished children, vaccination for COVID-19 should be prioritized for undernourished children.