Maxime Bedez

Oral dental foci of infection (ODFI), particularly those of periodontal origin, can trigger systemic inflammatory responses that may cause bacteremia for medically compromised patients. Although guidelines recommend detection and elimination of these foci, precise data on the distribution of periodontal oral dental foci of infection (PODFI) risk within these populations remain scarce. This study aimed to describe periodontal sources of infection in medically compromised patients using a periodontal examination and follow-up form and a recently developed PODFI risk levels classification. This observational, retrospective, cross-sectional, single-center study evaluated medically compromised patients with periodontitis in the dental surgery department of the Lille University Hospital between September 2024 and September 2025. Periodontitis was diagnosed according to the 2017 Classification of Periodontal Diseases established at the 2017 World Workshop. The primary outcome was the distribution of PODFI risk levels (moderate, high, very high). Secondary outcomes aimed to describe periodontal conditions in a specific population of medically compromised patients. Thirty-nine patients were included in this study. Evaluation of PODFI risk (n = 34) revealed a predominance of moderate-risk profiles (67.6%) and a significant proportion of high-risk profiles (32.4%); no low-risk or very high-risk profiles were observed. Periodontal inflammation was very common (92%), with a median of 26 bleeding on probing (BOP) sites and 71 plaque-positive sites, showing a positive correlation (R = 0.52, p = 0.002). Severe and active forms of periodontitis predominated (n = 39), with 74.4% of cases classified as stage III (28.2%) or stage IV (46.2%), and grade B was the most common (56.4%), followed by grade C (38.5%). Medically compromised patients have a high prevalence of severe and active periodontitis, with nearly one-third of them classified as being at high risk for infection. The recently developed periodontal oral dental foci of infection (PODFI) classification provides a structured and clinically relevant tool for stratifying infection risk and guiding treatment decisions. Prospective multicenter studies are needed to confirm the validity of these PODFI risk levels.

Objectives: This study evaluates the communication quality of French dentists when sharing oral dermatology cases on Facebook. Material and methods: A cross-sectional analysis was conducted over six months, examining cases shared in both general dentistry and specialized oral dermatology groups. A custom scoring grid assessed the cases for relevancy and misinformation, focusing on general presentation, dermatological criteria, and diagnostic hypotheses. Results: A total of 242 cases were analyzed. The study found that the average number of missing communication criteria was 6.21 ± 2.01 points, indicating significant variation in the quality of case presentations. The specialized oral dermatology group demonstrated higher-quality communication, with an average of 5.80 ± 1.84 missing points, compared to 7.00 ± 2.09 in the general dentistry group. Conclusions: These results suggest that specialized social media groups offer enhanced opportunities for professional learning and more detailed case presentations. However, the study also highlights the challenges of ensuring quality and consistency in online case sharing. It emphasizes the need for standardized guidelines to improve the educational potential of social media platforms for professional development in oral dermatology. Improved practices and guidelines could help maximize the benefits of these platforms for dentists and other health professionals.

This study aimed to evaluate the correlation between BMAT and bone quality, describe the long-term effects of ovariectomy on bone, and investigate BMAT's spatial distribution. Fifteen-months-old female Sprague‒Dawley rats were studied, comparing ovariectomized (OVX, n = 22) and sham-operated (SHAM, n = 11) groups at 6 months. Tibias were analyzed for bone microarchitecture, BMAT (microcomputed tomography), mineral parameters (quantitative backscattered electron imaging), and bone composition (Raman microspectroscopy). The OVX tibias showed severe trabecular bone loss (lower bone volume/total volume, p < 0.001) with increased BMAT (higher adipose volume per marrow volume, p < 0.001), decreased mineral content (lower calcium concentration, p < 0.001), and altered organic components (lower mineral/matrix ratio in new bone, p = 0.03 trabecular surface, p < 0.001 trabecular core). When the data are pooled over both groups (SHAM and OVX), the adipose volume/marrow volume ratio was negatively correlated with bone volume/total volume (r = − 0.79, p < 0.001) and mineral/matrix ratio (r = − 0.37, p = 0.04 trabecular surface; r = − 0.65, p < 0.001 trabecular core) and positively correlated with crystallinity (r = 0.55, p = 0.001 trabecular surface; r = 0.49, p = 0.006 trabecular core). The mineral/matrix ratio of trabecular surface new bone was strongly negatively correlated with the adipose compartment nearest to the bone surface. These findings suggest mechanisms underlying BMAT's role in bone resorption.

Introduction: This systematic review focuses on structural anomalies of enamel and dentin such as fluorosis (F), molar-incisor hypomineralization (MIH), amelogenesis imperfecta (AI), dentinogenesis imperfecta (DI), osteogenesis imperfecta (OI), and X-linked hypophosphatemia (XLH). These pathologies affect up to 31% of the population, posing challenges in the adhesion of direct restorations. The primary objective of this analysis is to examine the survival rate and/or bonding resistance of direct restorations on tissues affected by enamel and dentin disorders in humans. We aim to provide precise clinical recommendations for dentists to choose the appropriate bonding pretreatment for various enamel and dentin disorders. Methods: We systematically searched the medical literature to identify abstracts of interest indexed between 1993 and May 2024, from 4 databases (PubMed, PMC-PubMed, Web of Science and Cochrane Library). The results are reported following the PRISMA statement. The GRADE approach was used to assess the risk of bias. Results: The two authors included 27 studies out of the 600 identified. The data extracted from these studies are highly heterogeneous, and the mentioned bonding protocols are all different. 15 articles pertain to F, 7 to MIH, 5 to AI, and none focus on HSPM, dentin disorders and XLH. We identified 12 pretreatments of enamel or dentin (7 for F, 2 for MIH, and 3 for AI), including 3 strong recommendations. Additional studies are necessary to confirm the effectiveness of certain pretreatments. In developmental enamel defects, the main recommendation we collected is to bond on enamel with an etch-and-rinse technique on F and MIH. Considerations with lower strength of evidence include a deproteinization step on enamel on F, MIH and AI and modifications of the etching parameters on F and AI. The research strategy was registered on the Prospero platform (CRD42023447502).

Objectives: In this systematic review, we aimed to shed light on the frequency of dysgeusia among patients who had received hematopoietic stem cell transplantation and to determine factors that may be conducive to this buccal symptom. Materials and Methods: We conducted a systematic review of the literature on frequency of dysgeusia in patients who received hematopoietic stem cell transplant. We searched PubMed, PMC-PubMed, and Web of Science and followed the Preferred Reporting Items for Systematic reviews and Meta-analyses statement. Results: We identified 15 studies. The global frequency of dysgeusia varied greatly, ranging from 16.7% to 95%. Allogeneic stem cell transplant, including cells from other individuals, had more secondary effects than autologous transplant. Rate of dysgeusia was higher at the beginning of treatment. We found some differences according to populations, with dysgeusia increasing with age. Pediatric patients recovered more quickly, perhaps as a result of their faster cell division and development of taste receptors. Conclusions: Dysgeusia can greatly affect quality of life during graft treatment. The frequency can vary according to a number of factors, which are different targets in treatment. Symptom management during transplant seems to contribute to overall improvement in treatment.