Adam M. Pickrum
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Adam M. Pickrum has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Ashley H. Castellaw
Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, TN, USA
1 shared publication - Drew R. Jones
Metabolomics Core Resource Laboratory, NYU Langone Health, New York, USA
1 shared publication - Eric Bartnicki
Department of Microbiology, New York University Grossman School of Medicine, New York, USA
1 shared publication - Kamal Mohan Khanna
Department of Microbiology, New York University Grossman School of Medicine, New York, USA
1 shared publication - Keenan A. Lacey
Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA
1 shared publication - Sandra Gonzalez
Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA
1 shared publication
Latest Publications
- Open Access
- 26 July 2024
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 10 (30)
Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens
Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restriction (DWR) on susceptibility to multidrug-resistant pathogens is unknown. We report that DWR markedly increased susceptibility to systemic infection by ESKAPE pathogens. Using a murine bloodstream model of methicillin-resistant Staphylococcus aureus infection, we show that DWR leads to significantly increased mortality and morbidity. DWR causes increased bacterial burden, severe pathology, and increased numbers of phagocytes in the kidney. DWR appears to alter the functionality of these phagocytes and is therefore unable to control infection. Mechanistically, we show that DWR impairs the ability of macrophages to phagocytose multiple bacterial pathogens and efferocytose apoptotic neutrophils. Together, this work highlights the crucial impact that diet and hydration play in protecting against infection.
- 26 July 2024
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 10 (30)
Open AccessDietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens
Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restriction (DWR) on susceptibility to multidrug-resistant pathogens is unknown. We report that DWR markedly increased susceptibility to systemic infection by ESKAPE pathogens. Using a murine bloodstream model of methicillin-resistant Staphylococcus aureus infection, we show that DWR leads to significantly increased mortality and morbidity. DWR causes increased bacterial burden, severe pathology, and increased numbers of phagocytes in the kidney. DWR appears to alter the functionality of these phagocytes and is therefore unable to control infection. Mechanistically, we show that DWR impairs the ability of macrophages to phagocytose multiple bacterial pathogens and efferocytose apoptotic neutrophils. Together, this work highlights the crucial impact that diet and hydration play in protecting against infection.