David Cistulli
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
David Cistulli has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Anthony Steven Weiss
Charles Perkins Centre, University of Sydney, Camperdown, NSW 2006, Australia
1 shared publication - Dominic Ng
Cardiothoracic Surgical Department, Royal Prince Alfred Hospital, Sydney, Australia
1 shared publication - Hugh S. Paterson
Central Clinical School—Surgery, Faculty of Medicine and Health, the University of Sydney, Sydney, Australia
1 shared publication - Innes Wise
University of Sydney
1 shared publication John O’SUllivan
School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
1 shared publication- Lisa Partel
Sydney Imaging, Core Research Facilities, the University of Sydney, Sydney, Australia
1 shared publication
Latest Publications
- 1 August 2024
- Published by SAGE Publications in Tissue Engineering Part C: Methods
- Vol. 30 (8) , 335-342
Preventing Sheep Carotid Artery Spasm for Vascular Graft Surgery and Computed Tomography Angiography
The development of small-diameter vascular grafts requires testing in large animal models before advancing to clinical trials. Vascular graft interposition implantation in sheep carotid arteries (CAs) is the most widely used model, but ovine CAs are prone to severe spasm following surgical manipulation, potentially impairing graft performance assessment. There is paucity in the literature on reducing sheep CA spasm using effective vasodilator therapeutic protocols. In this study, four healthy Merino cross White Suffolk wethers (1–2 years, 52.1 ± 0.8 kg) underwent CT angiography and CA graft surgery. CT angiography using iodinated contrast agent was performed with innominate artery access through the CA or ascending aortic arch access through the femoral artery. Sheep then underwent right CA sham surgery or left CA vascular graft implantation. A variety of vasodilators, including papaverine, sodium nitroprusside, verapamil, and their combination, were tested for preventing or treating CA spasms intraoperatively. Blood flow was reassessed immediately after CA surgery using CT angiography. The results showed that innominate artery access through the CA for CT angiography in sheep induced presurgical CA spasm with reduced arterial flow. Conversely, ascending aortic arch access through the femoral artery for CT angiography did not cause CA spasm and maintained arterial flow. During CA graft surgery, surgical trauma induced CA spasm, which was prevented by localized intra-arterial administration of vasodilators papaverine hydrochloride and verapamil before significant surgical manipulation.
- 1 August 2024
- Published by SAGE Publications in Tissue Engineering Part C: Methods
- Vol. 30 (8) , 335-342
Preventing Sheep Carotid Artery Spasm for Vascular Graft Surgery and Computed Tomography Angiography
The development of small-diameter vascular grafts requires testing in large animal models before advancing to clinical trials. Vascular graft interposition implantation in sheep carotid arteries (CAs) is the most widely used model, but ovine CAs are prone to severe spasm following surgical manipulation, potentially impairing graft performance assessment. There is paucity in the literature on reducing sheep CA spasm using effective vasodilator therapeutic protocols. In this study, four healthy Merino cross White Suffolk wethers (1–2 years, 52.1 ± 0.8 kg) underwent CT angiography and CA graft surgery. CT angiography using iodinated contrast agent was performed with innominate artery access through the CA or ascending aortic arch access through the femoral artery. Sheep then underwent right CA sham surgery or left CA vascular graft implantation. A variety of vasodilators, including papaverine, sodium nitroprusside, verapamil, and their combination, were tested for preventing or treating CA spasms intraoperatively. Blood flow was reassessed immediately after CA surgery using CT angiography. The results showed that innominate artery access through the CA for CT angiography in sheep induced presurgical CA spasm with reduced arterial flow. Conversely, ascending aortic arch access through the femoral artery for CT angiography did not cause CA spasm and maintained arterial flow. During CA graft surgery, surgical trauma induced CA spasm, which was prevented by localized intra-arterial administration of vasodilators papaverine hydrochloride and verapamil before significant surgical manipulation.