Yan Xu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yan Xu has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Chenxi Yang
Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing University of Chinese Medicine , 138 Xianlin Road, Nanjing 210023
1 shared publication - Hongyu Zhao
Affiliation Department of Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
1 shared publication - Jie Dong
Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, PR China; School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, PR China
1 shared publication Jinyun Song
Clinical Research Center , The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, 1 Kangfu Street, Nanjing 210003, P.R. China
1 shared publication- Jun Chen
Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application，Nanjing University of Chinese Medicine, Nanjing 210023, China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
1 shared publication - Nannan Xue
Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application , Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, P.R. China
1 shared publication
Latest Publications
- Open Access
- 1 January 2024
- Published by Oxford University Press (OUP) in Burns & Trauma
- Vol. 12, tkae037
Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing
Calvatia gigantea (CG) is widely used as a traditional Chinese medicine for wound treatment. In this study, we aimed to determine the effects of CG extract (CGE) on diabetic wound healing and the commensal wound microbiome. A wound model was established using leptin receptor-deficient db/db mice, with untreated mice as the control group and CGE-treated mice as the treatment group. The wound healing rate, inflammation and histology were analyzed. Additionally, wound microbiome was evaluated via 16S ribosomal RNA (rRNA) gene sequencing. CGE significantly accelerated the healing of diabetic ulcer wounds, facilitated re-epithelialization, and downregulated the transcription levels of the inflammatory cytokines, interleukin-1β and tumor necrosis factor-α. Furthermore, CGE treatment positively affected the wound microbiome, promoting diversity of the microbial community and enrichment of Escherichia–Shigella bacteria in the CGE-treated group. Overall, CGE enhanced diabetic wound healing by modulating the wound microbiome and facilitating macrophage polarization during inflammation. These findings suggest modulation of the commensal wound microbiome using medicinal plants as a potential therapeutic strategy for diabetic wounds.
- 1 January 2024
- Published by Oxford University Press (OUP) in Burns & Trauma
- Vol. 12, tkae037
Open AccessReshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing
Calvatia gigantea (CG) is widely used as a traditional Chinese medicine for wound treatment. In this study, we aimed to determine the effects of CG extract (CGE) on diabetic wound healing and the commensal wound microbiome. A wound model was established using leptin receptor-deficient db/db mice, with untreated mice as the control group and CGE-treated mice as the treatment group. The wound healing rate, inflammation and histology were analyzed. Additionally, wound microbiome was evaluated via 16S ribosomal RNA (rRNA) gene sequencing. CGE significantly accelerated the healing of diabetic ulcer wounds, facilitated re-epithelialization, and downregulated the transcription levels of the inflammatory cytokines, interleukin-1β and tumor necrosis factor-α. Furthermore, CGE treatment positively affected the wound microbiome, promoting diversity of the microbial community and enrichment of Escherichia–Shigella bacteria in the CGE-treated group. Overall, CGE enhanced diabetic wound healing by modulating the wound microbiome and facilitating macrophage polarization during inflammation. These findings suggest modulation of the commensal wound microbiome using medicinal plants as a potential therapeutic strategy for diabetic wounds.