Putthiporn Charoenphun

Lymphoscintigraphy evaluates the lymphatic system using radiocolloid compounds like ^99mTc-sulfur colloid and ^99mTc-nanocolloid, which vary in particle size and distribution timing. A local in-house Dextran kit (15–40 nm) was developed in 2005 and began clinical use in 2008 to localize sentinel lymph nodes; diagnose lymphedema; and detect lymphatic leakage. The normal drainage pattern remains unexplored. We retrospectively analyzed 84 upper extremity lymphoscintigraphies from 2008 to 2021. ^99mTc in-house Dextran was intradermally injected into both hands, followed by whole-body imaging at specified intervals (≤15 min; 16–30 min; 31–45 min; 46–60 min), with some receiving delayed imaging. Visual and quantitative analyses recorded axillary and forearm lymph nodes and liver, kidney, and urinary bladder activity. Results showed 92% (77/84) upper extremity lymphatic tract visualization within 45 min. Axillary node detection rates increased from 46% (≤15 min) to 86% (46–60 min). Delayed imaging further revealed nodes. Epitrochlear or brachial node visualization was rare (4%, 3/84). Hepatic, renal, and urinary bladder activity was noted in 54%, 71%, and 93% at 1 h, respectively. The axillary node uptake ratio was minimal (99mTc in-house Dextran, offering insights into its clinical application

Yttrium-90 (⁹⁰Y) has been widely used in therapeutic nuclear medicine including in the selective internal radiation therapy with ⁹⁰Y-microsphere. In the procedure ⁹⁰Y source is protected within the radiation shielding apparatus made of perspex. However, bremsstrahlung radiation may be generated when ⁹⁰Y interacts with matter. The aim of this study was to evaluate bremsstrahlung radiation produced from radiation shielding apparatus using a scintillation detector and Monte Carlo simulation. The ⁹⁰Y source in glass vial was placed in the radiation shielding apparatus. Bremsstrahlung measurement and spectrum were performed and recorded using thallium-doped sodium iodide (NaI(Tl)) scintillation detector. Counting time and distance between the detector and apparatus were varied to obtain the optimal condition for bremsstrahlung measurement. Monte Carlo N-Particle (MCNP) 5 was used to simulate bremsstrahlung radiation with the same geometry used in the measurement. For experimental measurement results, the optimal distance and counting time were 10 cm and 120 s, respectively. Although the result of bremsstrahlung spectrum from the detector and simulation exhibited similar trend, markedly greater count rate was observed in simulations than in detector measurements. In conclusion, ⁹⁰Y bremsstrahlung can be produced from radiation protection apparatus and this can be evaluated by either measurement or simulation.