Haibo Ye
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Haibo Ye has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Qianqian Wang
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
2 shared publications - Xiaodong Zhang
College of Animal Science and Technology, Anhui Agricultural University, Hefei, China
2 shared publications - Zongjun Yin
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
2 shared publications - Fan Xie
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
1 shared publication - Fang Tian
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
1 shared publication - Hanyu Zhou
Anhui Province Key Laboratory of Local Livestock and Poultry, Genetic Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
1 shared publication
Latest Publications
- Open Access
Genome-Wide Association Study Identifies Candidate Genes for Body Size Traits in Wanyue Black Pigs
This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs, and genotyping was performed using a 50K SNP array. After stringent quality control and genotype imputation, approximately 4,697,453 high-quality autosomal variants were retained for subsequent genome-wide association study (GWAS), transcriptome-wide association study (TWAS), and phenome-wide association study (PheWAS). The GWAS identified four genome-wide significant loci, including rs343276492 and rs321308815. TWAS results revealed that the expression level of PTH2R was significantly associated with pituitary-related traits. In addition, selection signal analysis identified multiple genomic regions related to growth, development, and environmental adaptability, which were significantly enriched in pathways such as circadian rhythm regulation and the MAPK signaling pathway. These pathways play critical roles in growth regulation and adaptive evolution in Wanyue Black pigs. Collectively, this study provides valuable candidate genes and potential molecular markers for the genetic improvement and breeding of Wanyue Black pigs.
Open AccessGenome-Wide Association Study Identifies Candidate Genes for Body Size Traits in Wanyue Black Pigs
This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs, and genotyping was performed using a 50K SNP array. After stringent quality control and genotype imputation, approximately 4,697,453 high-quality autosomal variants were retained for subsequent genome-wide association study (GWAS), transcriptome-wide association study (TWAS), and phenome-wide association study (PheWAS). The GWAS identified four genome-wide significant loci, including rs343276492 and rs321308815. TWAS results revealed that the expression level of PTH2R was significantly associated with pituitary-related traits. In addition, selection signal analysis identified multiple genomic regions related to growth, development, and environmental adaptability, which were significantly enriched in pathways such as circadian rhythm regulation and the MAPK signaling pathway. These pathways play critical roles in growth regulation and adaptive evolution in Wanyue Black pigs. Collectively, this study provides valuable candidate genes and potential molecular markers for the genetic improvement and breeding of Wanyue Black pigs.
- Open Access
RNA-Seq Analysis Revealed circRNAs Associated with Resveratrol-Induced Apoptosis of Porcine Ovarian Granulosa Cells
Circular RNAs (circRNAs) are a class of circular non-coding RNAs that play essential roles in the intricate and dynamic networks governing cell growth, development, and apoptosis. Resveratrol (RSV), a non-flavonoid polyphenol, is known to participate in follicular development and ovulation. In our previous research, we established a model using porcine ovarian granulosa cells (POGCs) treated with resveratrol, which confirmed its regulatory effects on long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) within these cells. However, the influence of resveratrol on circRNA expression has not been thoroughly investigated. To explore how resveratrol affects circRNA levels in POGCs, we designed an experiment with three groups: a control group (CON, n = 3, 0 μM RSV), a low-dose RSV group (LOW, n = 3, 50 μM RSV), and a high-dose RSV group (HIGH, n = 3, 100 μM RSV) for circRNA sequencing. We identified a total of 10,045 candidate circRNAs from POGCs treated with different concentrations of resveratrol (0, 50, and 100 μM). Differential expression analysis indicated that 96 circRNAs were significantly altered in the LOW vs. CON group, while 109 circRNAs showed significant changes in the HIGH vs. CON group. These circRNAs were notably enriched in biological processes associated with cell metabolism, apoptosis, and oxidative stress. Functional enrichment analysis of the host genes revealed their involvement in critical signaling pathways, including mTOR, AMPK, and apoptosis pathways. Additionally, we identified potential miRNA sponge candidates among the differentially expressed circRNAs, particularly novel_circ_0012954 and novel_circ_0004762, which exhibited strong connectivity within miRNA-target networks. Our findings provide valuable insights into the regulatory mechanisms of circRNAs in the context of resveratrol-induced apoptosis in POGCs, highlighting their potential as innovative therapeutic targets in reproductive biology.
Open AccessRNA-Seq Analysis Revealed circRNAs Associated with Resveratrol-Induced Apoptosis of Porcine Ovarian Granulosa Cells
Circular RNAs (circRNAs) are a class of circular non-coding RNAs that play essential roles in the intricate and dynamic networks governing cell growth, development, and apoptosis. Resveratrol (RSV), a non-flavonoid polyphenol, is known to participate in follicular development and ovulation. In our previous research, we established a model using porcine ovarian granulosa cells (POGCs) treated with resveratrol, which confirmed its regulatory effects on long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) within these cells. However, the influence of resveratrol on circRNA expression has not been thoroughly investigated. To explore how resveratrol affects circRNA levels in POGCs, we designed an experiment with three groups: a control group (CON, n = 3, 0 μM RSV), a low-dose RSV group (LOW, n = 3, 50 μM RSV), and a high-dose RSV group (HIGH, n = 3, 100 μM RSV) for circRNA sequencing. We identified a total of 10,045 candidate circRNAs from POGCs treated with different concentrations of resveratrol (0, 50, and 100 μM). Differential expression analysis indicated that 96 circRNAs were significantly altered in the LOW vs. CON group, while 109 circRNAs showed significant changes in the HIGH vs. CON group. These circRNAs were notably enriched in biological processes associated with cell metabolism, apoptosis, and oxidative stress. Functional enrichment analysis of the host genes revealed their involvement in critical signaling pathways, including mTOR, AMPK, and apoptosis pathways. Additionally, we identified potential miRNA sponge candidates among the differentially expressed circRNAs, particularly novel_circ_0012954 and novel_circ_0004762, which exhibited strong connectivity within miRNA-target networks. Our findings provide valuable insights into the regulatory mechanisms of circRNAs in the context of resveratrol-induced apoptosis in POGCs, highlighting their potential as innovative therapeutic targets in reproductive biology.