Gisele da Costa Ramos
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Gisele da Costa Ramos has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Alessandra Jackeline Guedes de Moraes
Institute of Agricultural Sciences, Federal Rural University of the Amazon, Avenida Presidente Tancredo Neves, 2501, Belém 66077830, Brazil
1 shared publication - Andrey Moacir Do Rosario Marinho
Universidade Federal do Pará, Brazil
1 shared publication - André Salim Khayat
Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil
1 shared publication - Gleiciane Rodrigues dos Santos
Institute of Agricultural Sciences, Federal Rural University of the Amazon, Avenida Presidente Tancredo Neves, 2501, Belém 66077830, Brazil
1 shared publication - Ingryd Nayara de Farias Ramos
Oncology Research Center, Federal University of Pará, Rua dos Mundurucus, 4487, Belém 66073005, Brazil
1 shared publication - José Edson de Sousa Siqueira
Federal University of Pará, Rua Augusto Corrêa, 01, Guamá, Belém 66075110, Brazil
1 shared publication
Latest Publications
- Open Access
- 30 September 2024
- Published by MDPI AG in Preprints.org
Cytotoxic Activity of Koninginins Isolated from the Mangrove-Derived Endophytic Fungus Trichoderma sp.
The search for bioactive compounds for the treatment of several diseases has led to the study of endophytic fungi. Neoplastic diseases are among the most significant health concerns due to their high mortality rate, and there is a dearth of efficacious pharmaceutical agents for the treatment of cancer. Gastric cancer is one of the most aggressive forms of cancer and is among those with the highest mortality rates in Brazil. Accordingly, the objective of the present study was to identify compounds with cytotoxic activity from the mangrove-derived endophytic fungus Trichoderma sp. Isolation of the chemical compounds was conducted using chromatographic methods, while structural elucidation was achieved through the application of spectroscopic (NMR and UV) and spectrometric (MS) techniques. The fungus Trichoderma sp. was found to produce five distinct koninginins (A, B, C, E, and J). The organic phases of the extracts and isolated compounds were evaluated for their antimicrobial and cytotoxic potentials, respectively, through microdilution testing and the MTT method. In the cytotoxicity assay, both the AF extract and koninginin A demonstrated favorable outcomes, indicating their potential as promising anticancer therapeutic agents.
- 30 September 2024
- Published by MDPI AG in Preprints.org
Open AccessCytotoxic Activity of Koninginins Isolated from the Mangrove-Derived Endophytic Fungus Trichoderma sp.
The search for bioactive compounds for the treatment of several diseases has led to the study of endophytic fungi. Neoplastic diseases are among the most significant health concerns due to their high mortality rate, and there is a dearth of efficacious pharmaceutical agents for the treatment of cancer. Gastric cancer is one of the most aggressive forms of cancer and is among those with the highest mortality rates in Brazil. Accordingly, the objective of the present study was to identify compounds with cytotoxic activity from the mangrove-derived endophytic fungus Trichoderma sp. Isolation of the chemical compounds was conducted using chromatographic methods, while structural elucidation was achieved through the application of spectroscopic (NMR and UV) and spectrometric (MS) techniques. The fungus Trichoderma sp. was found to produce five distinct koninginins (A, B, C, E, and J). The organic phases of the extracts and isolated compounds were evaluated for their antimicrobial and cytotoxic potentials, respectively, through microdilution testing and the MTT method. In the cytotoxicity assay, both the AF extract and koninginin A demonstrated favorable outcomes, indicating their potential as promising anticancer therapeutic agents.