Nathielli Nayara Pauleti

The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan. The objective was to evaluate its antidiabetic and antioxidant activities, as well as its effects on pancreatic islets. Chromatographic analysis by HPLC–MS/MS revealed, for the first time in the genus Myrcia , the presence of phenolic acids such as vanillic acid, syringic acid, vanillin, p ‐coumaric acid, and salicylic acid. The extract demonstrated potent inhibition of the α‐glucosidase enzyme (IC ₅₀ = 0.17 ± 0.01 mg/mL), suggesting a hypoglycemic mechanism. At the biological level, treatment with the extract significantly reduced oxidative stress, as evidenced by a decrease in thiobarbituric acid reactive substances (TBA‐RS) and normalization of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px). Additionally, an improvement in the architecture of pancreatic islets was observed, with an increase in islet diameter in treated groups, suggesting potential cellular regeneration. Altogether, the extract of M. tijucensis has proven promising for studies in adjunctive therapy for Type 1 diabetes, helping to control glycemia, reduce oxidative stress, and preserve pancreatic islets.

Myrcia genus plants, like Myrcia pubipetala, traditionally used as hypoglycemic agents, hold promise for Type 1 Diabetes Mellitus (DM1) research but need more comprehensive chemical and pharmacological investigation. This is an experimental study involving controlled administration of treatments to a group of rats to assess their effects compared with a control group, investigating the effects of M. pubipetala on alloxan-induced Type 1 Diabetes Mellitus in rats. After the induction of diabetes, the rats received the hydroalcoholic extract (HAE) or aqueous fraction (AF) (25, 50, 100, or 150 mg kg-1) of M. pubipetala, or water. The results showed that diabetic rats presented cell damage in kidneys, oxidative stress, and high levels of glucose and triglycerides in their plasma and erythrocytes. The HAE (150 mg kg-1), per se, reduced lipid and protein oxidation, and the AF (150 mg kg-1) decreased lipoperoxidation. AF (150 mg kg-1), per se, decreased triglyceride levels. Conclusion: treatment with HAE and AF reduced oxidative damage, positively modulated antioxidant defenses, and exerted hypoglycemic and hypolipidemic effects, representing a potential adjuvant treatment for diabetes.