Jie Ma
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Jie Ma has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
Cong Peng
Department of Pain, Jingzhou Central Hospital, Jingzhou Hospital, Yangtze University, Jingzhou, Hubei 434000, China
1 shared publication- Cong Peng
Department of Pain, Jingzhou Central Hospital, Jingzhou Hospital, Yangtze University, Jingzhou, People’s Republic of China
1 shared publication
Latest Publications
- Open Access
- 4 October 2024
- Published by Taylor & Francis in All Life
- Vol. 17 (1)
Secoxyloganin inhibits growth of breast cancer MDA-MB-231 cells via induction of apoptosis and cell cycle arrest
- 4 October 2024
- Published by Taylor & Francis in All Life
- Vol. 17 (1)
Open AccessSecoxyloganin inhibits growth of breast cancer MDA-MB-231 cells via induction of apoptosis and cell cycle arrest
- Open Access
- 14 March 2024
- Published by Bangladesh Academy of Sciences in Bangladesh Journal of Pharmacology
- Vol. 19 (1) , 29-38
Nigella sativa plant extract inhibits the proliferation of MDA-MB-231 breast cancer cells via apoptosis and cell cycle arrest
The study was designed to evaluate the antiproliferative effects of Nigella sativa plant ethanol extract against MDA-MB-231 triple-negative breast cancer cells. DAPI and annexin V/propidium iodide staining assays were used to examine apoptosis. Results showed that N. sativa extract significantly (p<0.05) impeded the growth of MDA-MB-231 cells, with IC50 of 12.5 μg/mL. The colony-forming potential of MDA-MB-231 was significantly (p<0.05) decreased by the N. sativa extract-induced apoptosis. Increased expression of Bax, caspase-3, cleaved caspase-3, and cleaved PARP was also observed in the extract-treated MDA-MB-231 cells. Moreover, flow cytometric analysis showed that N. sativa extract triggered G0/G1 phase arrest in MDA-MB-231 cells. Collectively, N. sativa extract exhibits potent antiproliferative activity against triple-negative breast cancer cells and may be used as a source of anti-cancer agents.
- 14 March 2024
- Published by Bangladesh Academy of Sciences in Bangladesh Journal of Pharmacology
- Vol. 19 (1) , 29-38
Open AccessNigella sativa plant extract inhibits the proliferation of MDA-MB-231 breast cancer cells via apoptosis and cell cycle arrest
The study was designed to evaluate the antiproliferative effects of Nigella sativa plant ethanol extract against MDA-MB-231 triple-negative breast cancer cells. DAPI and annexin V/propidium iodide staining assays were used to examine apoptosis. Results showed that N. sativa extract significantly (p<0.05) impeded the growth of MDA-MB-231 cells, with IC50 of 12.5 μg/mL. The colony-forming potential of MDA-MB-231 was significantly (p<0.05) decreased by the N. sativa extract-induced apoptosis. Increased expression of Bax, caspase-3, cleaved caspase-3, and cleaved PARP was also observed in the extract-treated MDA-MB-231 cells. Moreover, flow cytometric analysis showed that N. sativa extract triggered G0/G1 phase arrest in MDA-MB-231 cells. Collectively, N. sativa extract exhibits potent antiproliferative activity against triple-negative breast cancer cells and may be used as a source of anti-cancer agents.