Rosa Murillo-Llergo
Research Subjects
Research Interests
Rosa Murillo-Llergo has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Giacomo Rossettini
School of Physiotherapy, University of Verona Verona Italy
1 shared publication - Jorge Hugo Villafañe
Universidad Europea de Madrid
1 shared publication - María Elena González-Álvarez
Escuela Internacional de Doctorado, Rey Juan Carlos University, 28008 Madrid, Spain
1 shared publication - María Manjón-Olmedillas
Laboratorio de Análisis Clínicos de la Dra. González Pérez, 28020 Madrid, Spain
1 shared publication - Silvia Turroni
Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology University of Bologna Bologna Italy
1 shared publication - Víctor Riquelme-Aguado
Department of Basic Health Sciences, Health Sciences Faculty, Rey Juan Carlos University, 28922 Madrid, Spain
1 shared publication
Latest Publications
- Open Access
Association Between Systemic Neuroinflammation, Pain Perception and Clinical Status in Fibromyalgia Patients: Cross-Sectional Study
Background: Fibromyalgia (FM) is characterized by chronic pain and a complex array of symptoms, with neuroinflammation implicated in its pathophysiology. Methods: This study aimed to explore the association between neuroinflammation, measured through interleukin levels (IL-1, IL-6, IL-8), and clinical outcomes in FM patients. Using a cross-sectional study design, blood levels of these interleukins were correlated with pain severity and disability, assessed via the Fibromyalgia Impact Questionnaire (FIQ) and pain measures. Results: Results indicated that IL-6 and IL-8 may particularly serve as biomarkers for pain severity and disability in FM patients, showing significant associations with worse clinical outcomes. Elevated IL-8 levels, for instance, correlated strongly with increased pain perception and higher disability scores. Conclusions: These findings suggest that specific interleukins are not only elevated in FM but are actively involved in the modulation of pain and disability, underscoring the role of systemic neuroinflammation in the clinical severity of FM. This study contributes to a deeper understanding of the inflammatory mechanisms in FM and underscores the potential of targeting interleukins in therapeutic strategies.
Open AccessAssociation Between Systemic Neuroinflammation, Pain Perception and Clinical Status in Fibromyalgia Patients: Cross-Sectional Study
Background: Fibromyalgia (FM) is characterized by chronic pain and a complex array of symptoms, with neuroinflammation implicated in its pathophysiology. Methods: This study aimed to explore the association between neuroinflammation, measured through interleukin levels (IL-1, IL-6, IL-8), and clinical outcomes in FM patients. Using a cross-sectional study design, blood levels of these interleukins were correlated with pain severity and disability, assessed via the Fibromyalgia Impact Questionnaire (FIQ) and pain measures. Results: Results indicated that IL-6 and IL-8 may particularly serve as biomarkers for pain severity and disability in FM patients, showing significant associations with worse clinical outcomes. Elevated IL-8 levels, for instance, correlated strongly with increased pain perception and higher disability scores. Conclusions: These findings suggest that specific interleukins are not only elevated in FM but are actively involved in the modulation of pain and disability, underscoring the role of systemic neuroinflammation in the clinical severity of FM. This study contributes to a deeper understanding of the inflammatory mechanisms in FM and underscores the potential of targeting interleukins in therapeutic strategies.