José Héctor Gibrán Fritz García
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
José Héctor Gibrán Fritz García has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
- Claudia Isabelle Keller Valsecchi
Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel
1 shared publication - Maria Felicia Basilicata
Institute of Molecular Biology (IMB), Mainz, Germany
1 shared publication
Latest Publications
- Open Access
- 30 October 2024
- Published by The Royal Society in Open Biology
- Vol. 14 (10) , 240177
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks
Sex-specific differences in lifespan and ageing are observed in various species. In humans, women generally live longer but are frailer and suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic instability, telomere attrition or loss of proteostasis, exhibit sex-specific patterns. Sex chromosomes and sex hormones, as well as the epigenetic regulation of the inactive X chromosome, have been shown to affect lifespan and age-related diseases. Here we review the current knowledge on the biological basis of sex-biased ageing. While our review is focused on humans, we also discuss examples of model organisms such as the mouse, fruit fly or the killifish. Understanding these molecular differences is crucial as the elderly population is expected to double worldwide by 2050, making sex-specific approaches in the diagnosis, treatment, therapeutic development and prevention of age-related diseases a pressing need.
- 30 October 2024
- Published by The Royal Society in Open Biology
- Vol. 14 (10) , 240177
Open AccessSex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks
Sex-specific differences in lifespan and ageing are observed in various species. In humans, women generally live longer but are frailer and suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic instability, telomere attrition or loss of proteostasis, exhibit sex-specific patterns. Sex chromosomes and sex hormones, as well as the epigenetic regulation of the inactive X chromosome, have been shown to affect lifespan and age-related diseases. Here we review the current knowledge on the biological basis of sex-biased ageing. While our review is focused on humans, we also discuss examples of model organisms such as the mouse, fruit fly or the killifish. Understanding these molecular differences is crucial as the elderly population is expected to double worldwide by 2050, making sex-specific approaches in the diagnosis, treatment, therapeutic development and prevention of age-related diseases a pressing need.