Branimir Gruica
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Branimir Gruica has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Jelena Galić
Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
1 shared publication - Marina Pehlić
Department of Gynecology and Obstetrics, University Hospital of Split, 21000 Split, Croatia
1 shared publication - Marko Vulić
Department of Gynecology and Obstetrics, University Hospital of Split, 21000 Split, Croatia
1 shared publication - Mila Radan
Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
1 shared publication - Sandra Marijan
Department of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia
1 shared publication - Stipe Dumancic
Department of Obstetrics and Gynecology, University Hospital Center Split, Spinčićeva 1, 21000 Split, Croatia
1 shared publication
Latest Publications
- Open Access
- 18 November 2024
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 25 (22) , 12371
Untargeted Urinary Volatilomics Reveals Hexadecanal as a Potential Biomarker for Preeclampsia
Preeclampsia (PE) is a severe hypertensive pregnancy disorder characterized by endothelial dysfunction, placental ischemia and oxidative stress; however, reliable non-invasive biomarkers for early detection are limited. In this study, untargeted solid-phase microextraction with gas chromatography–mass spectrometry (SPME-GC-MS) was used to analyze volatile organic compounds in the urine of 45 women with PE and 46 healthy controls. Among the 29 metabolites identified, hexadecanal—a product of lipid peroxidation and sphingolipid metabolism—was found to be the most significant, with an area under the receiver operating characteristic (ROC) curve of 0.618, highlighting its diagnostic potential. This result emphasizes the role of hexadecanal in oxidative stress and placental dysfunction, which are central to the pathophysiology of PE. The results support hexadecanal as a potential non-invasive biomarker while demonstrating the efficacy of SPME-GC-MS in identifying metabolic disorders associated with PE, paving the way for further research to confirm its clinical utility for early diagnosis and risk assessment.
- 18 November 2024
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 25 (22) , 12371
Open AccessUntargeted Urinary Volatilomics Reveals Hexadecanal as a Potential Biomarker for Preeclampsia
Preeclampsia (PE) is a severe hypertensive pregnancy disorder characterized by endothelial dysfunction, placental ischemia and oxidative stress; however, reliable non-invasive biomarkers for early detection are limited. In this study, untargeted solid-phase microextraction with gas chromatography–mass spectrometry (SPME-GC-MS) was used to analyze volatile organic compounds in the urine of 45 women with PE and 46 healthy controls. Among the 29 metabolites identified, hexadecanal—a product of lipid peroxidation and sphingolipid metabolism—was found to be the most significant, with an area under the receiver operating characteristic (ROC) curve of 0.618, highlighting its diagnostic potential. This result emphasizes the role of hexadecanal in oxidative stress and placental dysfunction, which are central to the pathophysiology of PE. The results support hexadecanal as a potential non-invasive biomarker while demonstrating the efficacy of SPME-GC-MS in identifying metabolic disorders associated with PE, paving the way for further research to confirm its clinical utility for early diagnosis and risk assessment.