Isis Wanessa Ferreira dos Santos
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Isis Wanessa Ferreira dos Santos has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Amanda de Azevedo Valle
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-000, São Paulo, Brazil
1 shared publication - Ana Carolina Luchiari
Department of Physiology & Behavior, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, Brazil
1 shared publication - Bruno Fiorelini Pereira
Experimental Danio rerio Facility (BEDAR), Universidade Federal de São Paulo – campus Diadema, Diadema, São Paulo, Brazil
1 shared publication - Flávio Kiyoshi Tominaga
Experimental Danio rerio Facility (BEDAR), Universidade Federal de São Paulo - campus Diadema, Diadema, Brazil
1 shared publication - Fábio Kummrow
Department of Pharmaceutical Sciences - Campus Diadema, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.(F. K.), Brazil
1 shared publication - Gisele Giannocco
Molecular and Translational Endocrinology Laboratory, Thyroid Disease Center, Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, Brazil
1 shared publication
Latest Publications
- Open Access
- 27 November 2024
- Published by MDPI AG in Microplastics
- Vol. 3 (4) , 717-729
Microplastic Interference with Fipronil Toxicity to Zebrafish Embryonic Development
Environmental contamination from mixtures of chemical substances and materials resulting from anthropogenic activities has adverse effects on aquatic biota. Fipronil (FP) is an insecticide widely used in agriculture and public health and is frequently detected in environmental compartments. Microplastics (MPs) represent another class of contaminants that have raised concerns due to their ability to adsorb pollutants, potentially acting as a vector. This study evaluated the influence of polyethylene microplastics on the toxicity of FP in zebrafish (Danio rerio) embryos/larvae. Zebrafish embryos were exposed to aqueous suspension containing purified FP and the FP + MP mixtures for 120 h. Mortality, teratogenicity and cardiotoxicity were observed during the zebrafish development. Larvae were more sensitive to FP than the embryo. The presence of MPs reduced lethality; however, no significant changes were observed for sublethal endpoints. Our findings demonstrate the acute impact of FP on zebrafish embryos/larvae, demonstrating that MPs interfere with toxicity. Therefore, understanding the mechanisms of interaction between contaminants of different classes is essential for predicting the associated risks to biota.
- 27 November 2024
- Published by MDPI AG in Microplastics
- Vol. 3 (4) , 717-729
Open AccessMicroplastic Interference with Fipronil Toxicity to Zebrafish Embryonic Development
Environmental contamination from mixtures of chemical substances and materials resulting from anthropogenic activities has adverse effects on aquatic biota. Fipronil (FP) is an insecticide widely used in agriculture and public health and is frequently detected in environmental compartments. Microplastics (MPs) represent another class of contaminants that have raised concerns due to their ability to adsorb pollutants, potentially acting as a vector. This study evaluated the influence of polyethylene microplastics on the toxicity of FP in zebrafish (Danio rerio) embryos/larvae. Zebrafish embryos were exposed to aqueous suspension containing purified FP and the FP + MP mixtures for 120 h. Mortality, teratogenicity and cardiotoxicity were observed during the zebrafish development. Larvae were more sensitive to FP than the embryo. The presence of MPs reduced lethality; however, no significant changes were observed for sublethal endpoints. Our findings demonstrate the acute impact of FP on zebrafish embryos/larvae, demonstrating that MPs interfere with toxicity. Therefore, understanding the mechanisms of interaction between contaminants of different classes is essential for predicting the associated risks to biota.