Mengya Pan

Terahertz (THz) fingerprint spectroscopy enables label-free identification of molecular vibrational signatures, but trace biomolecular absorption is too weak to be reliably resolved in free-space measurements. To address this limitation, we propose a four-degree-of-freedom geometrically encoded THz metasurface for broadband multichannel fingerprint sensing. The substrate-free self-supporting aluminum structure incorporates four independently tunable geometric parameters: gap angle θ, outer ring radius R, scaling factor S, and ring width W. By regulating these parameters, multiple resonance-tuning pathways are established, enabling designable multiband spectral coverage over 0.6–1.4 THz and flexible matching with the fingerprint bands of L-hydroxyproline (L-HYP). Numerical simulations show that the metasurface achieves a refractive-index sensitivity of 512.66 GHz/RIU with a linear fitting coefficient of R² = 0.99708 and a mean Q factor of 4.72. For biomolecular fingerprint sensing, the encoded resonances overlap with the L-HYP absorption bands near 0.73 and 1.17 THz, producing AIT-like spectral modulation and envelope-derived attenuation enhancement. Compared with an unstructured analyte reference, the valid 0.73 THz readout gives enhancement factors of 5.76 and 7.09 for the R and S channels, respectively, while the four encoded channels provide enhancement factors of 3.53–4.45 at 1.17 THz. This design provides a compact strategy for broadband multichannel THz fingerprint enhancement, offering a promising route for monitoring collagen-metabolism-related biomarkers and advancing label-free biochemical sensing, fibrosis-related molecular screening, and integrated broadband THz detection.

Terahertz (THz) fingerprint detection is central to identifying characteristic absorption fingerprints of biomolecules derived from their intrinsic rotational and vibrational modes. The development of guided-mode resonance (GMR) technology together with pixelated design offers a new approach to enhance the recognition capability of such fingerprint spectra. Here, a novel secondary grating metasurface based on cycloolefin polymer (COP) is proposed, which adopts an ultra-minimalist dual-pixel complementary architecture to excite high-quality (Q)-factor GMR. Its spectral resolution does not exceed 50 GHz, enabling precise capture of target molecular characteristic information and meeting the requirements of broadband fingerprint sensing. More importantly, the design regulates the dual-pixel grating units through parameter gradient optimization and incorporates a dual regulation mode of static pixel-targeted coverage and dynamic angle fine tuning. By adjusting geometric parameters and incident angles, broadband coverage from 1.15 THz to 2.20 THz is achieved, which can accurately match the multi-fingerprint detection requirements of glutamic acid (Glu) and glutamine (Gln). This metasurface sensor, integrating the advantages of pixelation and high-Q-factor GMR characteristics, provides an effective strategy for enhanced broadband THz fingerprint sensing and shows broad application potential in the field of biochemical trace detection.

Terahertz (THz) metasurface biosensors still encounter difficulties in simultaneously achieving high spectral resolution and stable readout across different refractive-index regimes. In this work, an all-liquid-crystal-polymer (LCP) THz metasensor supporting dual quasi-bound states in the continuum (quasi-BIC) resonances is proposed for regime-dependent refractive-index sensing. By introducing structural asymmetry into a periodic LCP cubic-cluster metasurface, two pronounced resonances are generated with quality factors (Q factors) of 6811 and 2526, respectively. Near-field distributions and multipole decomposition analysis indicate that the two resonances possess distinct electromagnetic features, which result in different responses to surrounding dielectric perturbations. In the low-refractive-index range of 1.0–1.5, the two resonance frequencies exhibit a linear variation with refractive index, yielding sensitivities of 122 GHz/RIU and 179 GHz/RIU, respectively. These dual-mode linear responses further offer a foundation for concentration- and temperature-related evaluation through analyte refractive-index mapping. In the higher-refractive-index range of 1.5–1.8, the intermodal frequency difference shows improved linearity with refractive index compared with the individual resonance frequencies, enabling a differential readout scheme with enhanced robustness against common perturbations. The results demonstrate that the proposed all-LCP dual-quasi-BIC metasensor not only enables high-resolution THz refractive-index sensing, but also establishes a regime-dependent spectral readout approach for different dielectric-response intervals.

Metasurface biosensing confronts a significant challenge in simultaneously achieving broadband response, high quality-factor (Q-factor), and ultrahigh sensitivity for specific trace-analyte detection at terahertz (THz) frequencies. Recently, quasi-bound states in the continuum (QBICs) metasurfaces provided enhanced light–matter interactions and ultrahigh sensitivity in narrow resonant bands. In this work, an angle-scanning QBIC metasurface array pixelated with just 5 × 5 scaling units is proposed to achieve an ultra-broad spectrum from 1 to 2.8 THz for fingerprint bio-detection. The symmetry-protected QBIC is excited by breaking the symmetry of copper block dimer resonator structures, achieving a Q-factor of 20 and a sensitivity of 500 GHz/RIU. A spectral step of approximately 10 GHz is demonstrated in this approach, and glutamic acid and glutamine are specifically detected, with detection limits reaching 15.4 μg/cm² and 14.7 μg/cm². This design provides a novel approach for achieving ultra-wideband, specific, and highly sensitive detection. This capability offers an efficient strategy for monitoring tumor metabolic biomarkers and paves the way for applications in early diagnosis and advanced broadband THz detection.

Terahertz (THz) spectroscopy, an advanced label-free sensing method, offers significant potential for biomolecular detection and quantitative analysis in biological samples. Although broadband fingerprint enhancement compensates for limitations in detection capability and sensitivity, the complex optical path design in operation restricts its broader adoption. This paper proposes a multi-degree-of-freedom stretchable metasurface that supports magnetic dipole resonance to enhance the broadband THz fingerprint detection of trace analytes. The metasurface substrate and unit cell structures are constructed using polydimethylsiloxane. By adjusting the sensor’s geometric dimensions or varying the incident angle within a narrow range, the practical optical path is significantly simplified. Simultaneously, the resonance frequency of the transmission curve is tuned, achieving high sensitivity for effectively detecting cinnamoylglycine. The results demonstrate that the metasurface achieves a high-quality factor of 770.6 and an excellent figure of merit of 777.2, significantly enhancing the THz sensing capability. Consequently, the detection sensitivity for cinnamoylglycine can reach 24.6 µg·cm⁻². This study offers critical foundations for applying THz technology to biomedical fields, particularly detecting urinary biomarkers for diseases like gestational diabetes.

THz waves have garnered significant attention across multiple domains, particularly in high-sensitivity sensing applications. Metamaterials are applicable in THz sensors owing to their exceptional sensitivity, particularly in refractive index measurement and pesticide identification. This paper proposes a THz metamaterial sensor for detecting ether kresoxim-methyl. The sensor comprises a periodic array of silicon cylindrical trimers organized on a silicon substrate. Resonances in the guided mode, dictated by bound states in the continuum spectrum, can be stimulated by meticulously configuring the geometric arrangement of the silicon column trimer. The sensor demonstrates a Q-value of up to 143 at the resonant frequency. The detection of pesticide residues achieved high sensitivity and specificity, with a detection limit of 37.74 μg/cm². This study presents a novel alternative for THz metamaterial sensors characterized by high sensitivity and a broad spectrum of pesticide concentration detection. The sensor platform developed in this paper, utilizing conventional CMOS technology, is posited as a potential detection instrument for herbicide and pesticide residues in agriculture and food.