Jiwoo Park

Purpose of Review Air pollution has been raised as a novel risk factor for osteoporosis, which impose a huge burden on both individuals and society. Thus, summarizing and discussing previous results on the association between ambient air pollution and osteoporosis can be informative in synthesizing the current evidence and improving relevant action plans. Recent findings Recent studies reported that long-term exposure to ambient air pollution is associated with an increased risk of osteoporosis and related outcomes; however, the studied populations, air pollutants, areas, and results on high-risk populations are heterogeneous. Among air pollutants, long-term exposure to PM_2.5 showed an association with osteoporosis or osteoporosis-related fracture in general. Summary Recent scientific evidence indicates that ambient air pollution is a potential risk factor for osteoporosis and related outcomes. Further research is warranted on how air pollution impacts these outcomes including for high-risk populations with consistent effect modifiers, and analytic methodologies.

Single-walled carbon nanotubes (SWCNTs) have gained significant interest for their potential in biomedicine and nanoelectronics; particularly, the functionalization of SWCNTs with single-stranded DNA (ssDNA) enables precise control of SWCNT alignment and the development of optical and electronic biosensors. Our study addresses gaps in understanding by employing high-throughput systematic evolution, enriching high-affinity ssDNA sequences from a vast random library. We identify specific base compositions and patterns that govern the binding affinity between ssDNA and SWCNTs. Molecular dynamics simulation validates the stable ssDNA conformation on SWCNT and reveal the pivotal role of hydrogen bonds in this interaction. Additionally, we demonstrate machine learning's capacity to accurately distinguish high-affinity ssDNA sequences, providing an accessible model on a dedicated webpage (http://service.k-medai.com/ssdna4cnt). These findings open new avenues for high-affinity ssDNA-SWCNT constructs for enduring and sensitive molecular detection across diverse scientific disciplines.