Shunmuga Vadivu Ramalingam
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Shunmuga Vadivu Ramalingam has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Afrin Khan Ajmal
Research Scholar of English Department of English and Foreign Languages SRM Institute of Science and Technology Ramapuram Chennai India
1 shared publication - Karnan Ramachandran
Annai Vailankanni Arts and Science College, (Affiliated to Bharathidasan University)
1 shared publication - Mohammad Khalid Al-Sadoon
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
1 shared publication - Ramachandran Vinayagam
Department of Biotechnology, College of Life and Applied Sciences Yeungnam University Gyeongsan Republic of Korea
1 shared publication - Senthil Bakthavatchalam
Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Ramapuram Campus, Chennai 600089, Tamil Nadu, India
1 shared publication - Vasthi Gnanarani Soloman
Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Ramapuram Campus, Chennai 600089, Tamil Nadu, India
1 shared publication
Latest Publications
- Open Access
- 7 December 2024
- Published by MDPI AG in Antibiotics
- Vol. 13 (12) , 1193
Potential Antimicrobial and Cytotoxic Activity of Caralluma indica Seed Extract
Background: Plant-derived phytochemicals are crucial in fighting bacterial infections and in cancer therapy. Objective: This study investigates the phytochemical composition of the ethanolic extract obtained from Caralluma indica (C. indica) seeds and assesses its antimicrobial, anticancer, and antioxidant activities. Results: GC-MS analysis found 30 phytochemicals in C. indica seeds, including 5 bioactive compounds that have been shown to have antioxidant, antimicrobial, and cytotoxicity properties, through in silico evaluation. Phytochemical screening of C. indica identified and measured the phenolic compounds, providing insight into its bioactive potential and therapeutic properties. C. indica exhibited robust antioxidant capacity (DPPH, ABTS, nitric oxide, and H2O2 radical scavenging) alongside potent antimicrobial activity against oral pathogen and cytotoxicity activity on a human oral squamous carcinoma cell line (OECM-1) (EC50 of 169.35 µg/mL) and yeast cell Saccharomyces cerevisiae (215.82 µg/mL), with a selective index of 1.27. The subminimum % MBC/MFC of C. indica significantly reduced biofilm formation against oral pathogens (p < 0.05). Molecular docking studies showed a strong correlation (r = 0.862) between antifungal and anticancer targets, suggesting that the antimicrobial agents in C. indica contribute to cancer prevention mechanisms. Conclusions: These findings propose C. indica seeds as promising candidates for combating oral pathogens, inhibiting biofilm formation, and reducing the risk of oral cancer progression.
- 7 December 2024
- Published by MDPI AG in Antibiotics
- Vol. 13 (12) , 1193
Open AccessPotential Antimicrobial and Cytotoxic Activity of Caralluma indica Seed Extract
Background: Plant-derived phytochemicals are crucial in fighting bacterial infections and in cancer therapy. Objective: This study investigates the phytochemical composition of the ethanolic extract obtained from Caralluma indica (C. indica) seeds and assesses its antimicrobial, anticancer, and antioxidant activities. Results: GC-MS analysis found 30 phytochemicals in C. indica seeds, including 5 bioactive compounds that have been shown to have antioxidant, antimicrobial, and cytotoxicity properties, through in silico evaluation. Phytochemical screening of C. indica identified and measured the phenolic compounds, providing insight into its bioactive potential and therapeutic properties. C. indica exhibited robust antioxidant capacity (DPPH, ABTS, nitric oxide, and H2O2 radical scavenging) alongside potent antimicrobial activity against oral pathogen and cytotoxicity activity on a human oral squamous carcinoma cell line (OECM-1) (EC50 of 169.35 µg/mL) and yeast cell Saccharomyces cerevisiae (215.82 µg/mL), with a selective index of 1.27. The subminimum % MBC/MFC of C. indica significantly reduced biofilm formation against oral pathogens (p < 0.05). Molecular docking studies showed a strong correlation (r = 0.862) between antifungal and anticancer targets, suggesting that the antimicrobial agents in C. indica contribute to cancer prevention mechanisms. Conclusions: These findings propose C. indica seeds as promising candidates for combating oral pathogens, inhibiting biofilm formation, and reducing the risk of oral cancer progression.