A. G. Kochetov

The aim of the study was to evaluate the efficacy of fluorothiazinone in a real-world clinical setting. Material and methods. The paper presents the initial results of clinical application of combination therapy for infectious and inflammatory complications following endourological surgeries using the new antibacterial drug fluorothiazinone in a urology department. Clinical and laboratory data were analyzed, and the results of microbiological examination methods were examined. Results. Analysis of body temperature dynamics revealed a significant decrease in temperature in the fluorothiazinone group, with the average body temperature on day 3 being closer to normal than in the control group. Clinical improvement was observed in 92.3 % of patients on day 3 of therapy, compared to 37 % in the control group. In the fluorothiazinone group, stable positive dynamics in reducing inflammatory markers were observed on day 3 of therapy. Fluorothiazinone has been demonstrated to be effective in suppressing biofilm formation, and significant cytotoxicity suppression of clinical isolates of K. pneumoniae has been demonstrated in vitro. Conclusion: Given the multidrug resistance of hospital-acquired strains, timely initiation of antibacterial therapy based on local microbiological monitoring in combination with the new drug fluorothiazinone has proven effective in treating this complex group of patients.

Introduction. Viscosipathy is a violation of the process of dilution of sperm, it is considered one of the possible causes of male infertility. Views on the causes of this condition and its pathogenesis are contradictory. The purpose of this review was to systematize publications on this issue. Materials and methods. As a result of searching for relevant publications in PubMed databases and eLibrary.ru according to the following keywords «male infertility», «viscosipathy», «pathogenesis», «diagnosis», «treatment», 31 publications were selected and included in this review. Results and discussion. Seminal plasma plays an essential role in ensuring normal sperm motility and their protection. The study of sperm viscosity is a mandatory element of its analysis. One of the key etiological factors in the development of viscosipathy is inflammation of the accessory sex glands, which leads to a violation of their function and an increase in the level of oxidative stress. Changes in the content of trace elements and proteolytic fermets in the spermatic plasma are another reason for the development of viscosipathy. This condition can worsen fertility due to impaired sperm motility. Treatment of viscosipathy includes medications that contribute to the resolution of the inflammatory process in the accessory sex glands, as well as enzyme therapy.Conclusions. Viscosipathy is one of the possible causes of male infertility, which can be diagnosed based on a spermogram. The main reason for its occurrence is a violation of the function of the accessory sex glands, most often due to inflammation. Due to the current lack of unified views on the etiology and pathogenesis of this condition, further research in this direction is needed.

The article presents 2 clinical observations of treatment of patients with stone encrustation and stone formation on the vesicular and pelvic coils of the internal ureteral stent placed after endoscopic stone removal. In both cases, for different reasons, there was a delay in planned hospitalization for stent removal.