Hélène Larrue
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Hélène Larrue has a total of 15 co-authors. Here are the top co-authors by number of shared publications:
- Caroline Jezéquel
CHU Rennes, Rennes, France
1 shared publication - Christine Silvain
Centre Hospitalier Universitaire Poitiers et Université de Poitiers, Hépato-Gastroentérologie, Poitiers, France
1 shared publication - Delphine Weill
Université de Franche-Comté, EFS, INSERM, UMR RIGHT, CHU de Besançon, Besançon, France
1 shared publication - Dominique Thabut
Brain-Liver Pitié Salpêtrière (BLIPS) Study Group, APHP Sorbonne Université, Centre de Recherche Saint-Antoine, Maladies Métaboliques, Biliaires Et Fibro- Inflammatoire du Foie, INSERM UMR_S 938, Paris, France
1 shared publication - Emilie Malézieux
CHU de Montpellier, Montpellier, France
1 shared publication - Hélène Regnault
AP-HP, Hôpital Henri Mondor, Service d’Hépatologie, Créteil, France
1 shared publication
Latest Publications
- 29 December 2024
- Published by Springer Nature in Obesity Surgery
- Vol. 35 (2) , 395-405
Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Bridge to Bariatric Surgery in Morbidly Obese Patients with Cirrhosis and Clinically Significant Portal Hypertension
Background In cirrhotic patients, portal hypertension increases mortality after surgery. We evaluated the impact of pre-operative transjugular intrahepatic portosystemic shunt (TIPS) on the outcomes of bariatric surgery in cirrhosis. Methods Multicentric retrospective cohort. The decision for TIPS placement has been made according to hepatic venous pressure gradient (HVPG) values and centers’ policy. The primary outcome: 1-year decompensation-free survival; secondary outcomes: 1-year acute-on-chronic liver failure (ACLF) and survival. Results Fifty-three patients were included (2010–2022): 92% Child–Pugh A, MELD score 8, age 55 years, BMI 38.3 ± 13 kg/m2, 9 (18%) had TIPS. At baseline, patients with TIPS had more esophageal varices (89% vs 10%, p < 0.001), more previous decompensations (22% vs 0%, p = 0.002), and a higher HVPG (14 vs 7 mmHg, p < 0.001). All patients in the TIPS group had clinically significant portal hypertension vs 11% of patients without TIPS, p < 0.001. One-year decompensation-free survival was 77.8% and 93.2% in patients with and without TIPS, p = 0.064. ALCF occurred in 3 patients (6.8%) without TIPS and none with TIPS. All patients were alive 1 year after surgery. Conclusions In patients with cirrhosis and clinically significant portal hypertension (CSPH) undergoing bariatric surgery, TIPS placement was safe and had similar outcomes after surgery as patients without TIPS.
- 29 December 2024
- Published by Springer Nature in Obesity Surgery
- Vol. 35 (2) , 395-405
Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Bridge to Bariatric Surgery in Morbidly Obese Patients with Cirrhosis and Clinically Significant Portal Hypertension
Background In cirrhotic patients, portal hypertension increases mortality after surgery. We evaluated the impact of pre-operative transjugular intrahepatic portosystemic shunt (TIPS) on the outcomes of bariatric surgery in cirrhosis. Methods Multicentric retrospective cohort. The decision for TIPS placement has been made according to hepatic venous pressure gradient (HVPG) values and centers’ policy. The primary outcome: 1-year decompensation-free survival; secondary outcomes: 1-year acute-on-chronic liver failure (ACLF) and survival. Results Fifty-three patients were included (2010–2022): 92% Child–Pugh A, MELD score 8, age 55 years, BMI 38.3 ± 13 kg/m2, 9 (18%) had TIPS. At baseline, patients with TIPS had more esophageal varices (89% vs 10%, p < 0.001), more previous decompensations (22% vs 0%, p = 0.002), and a higher HVPG (14 vs 7 mmHg, p < 0.001). All patients in the TIPS group had clinically significant portal hypertension vs 11% of patients without TIPS, p < 0.001. One-year decompensation-free survival was 77.8% and 93.2% in patients with and without TIPS, p = 0.064. ALCF occurred in 3 patients (6.8%) without TIPS and none with TIPS. All patients were alive 1 year after surgery. Conclusions In patients with cirrhosis and clinically significant portal hypertension (CSPH) undergoing bariatric surgery, TIPS placement was safe and had similar outcomes after surgery as patients without TIPS.