Everton Nencioni
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Everton Nencioni has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Camila Perea
Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, Brazil
1 shared publication - Fábio Thimoteo
Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, Brazil
1 shared publication - Gilmara Barros de Lima
Center for Natural and Human Sciences, Federal University of ABC, Brazil
1 shared publication - Rafaela Fuzaro Alves Pinto
Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, Brazil
1 shared publication - Sergio Daishi Sasaki
Center for Natural and Human Sciences, Federal University of ABC, Brazil
1 shared publication
Latest Publications
- Open Access
- 7 January 2025
- Published by MDPI AG in Biomolecules
- Vol. 15 (1) , 75
TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. As we uncover more about TMPRSS2’s role in pathogenesis, it could open new doors for therapies to combat future outbreaks.
- 7 January 2025
- Published by MDPI AG in Biomolecules
- Vol. 15 (1) , 75
Open AccessTMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. As we uncover more about TMPRSS2’s role in pathogenesis, it could open new doors for therapies to combat future outbreaks.