Natalia V. Gorphinchenko
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Natalia V. Gorphinchenko has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Vladimir A. Kokorekin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia
2 shared publications - Vladimir M. Khodonov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia
2 shared publications - Anna M. Sukhanova
A. P. Nelubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation, Trubetskaya Str. 8-2, 119991 Moscow, Russia
1 shared publication - Galina Vladislavovna Ramenskaya
I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)
1 shared publication - Nikolay A. Shulga
Department of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, Russia
1 shared publication - Sergey Dementyev
The Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119048 Moscow, Russia
1 shared publication
Latest Publications
- Open Access
7-Methoxy-3,4-dithiocyanato-1H-indole
In this work, we carried out a double C–H thiocyanation of 7-methoxy-1H-indole to afford the novel 7-methoxy-3,4-dithiocyanato-1H-indole in good yield. The structure of the target product was confirmed by 1H and 13C NMR spectroscopy, FT-IR spectroscopy, and HRMS.
Open Access7-Methoxy-3,4-dithiocyanato-1H-indole
In this work, we carried out a double C–H thiocyanation of 7-methoxy-1H-indole to afford the novel 7-methoxy-3,4-dithiocyanato-1H-indole in good yield. The structure of the target product was confirmed by 1H and 13C NMR spectroscopy, FT-IR spectroscopy, and HRMS.
- Open Access
1-(1-Methyl-5-thiocyanato-1H-pyrrol-2-yl)-3-nitro-1H-1,2,4-triazole
A two-stage synthesis of the novel compound 1-(1-methyl-5-thiocyanato-1H-pyrrol-2-yl)-3-nitro-1H-1,2,4-triazole utilizing electrochemistry as an environmentally benign tool is reported. The structure of the target molecule was confirmed by 1H and 13C NMR spectroscopy and HRMS. The compound exhibits antibacterial and antifungal activity comparable to chloramphenicol, ciprofloxacin, and fluconazole.
Open Access1-(1-Methyl-5-thiocyanato-1H-pyrrol-2-yl)-3-nitro-1H-1,2,4-triazole
A two-stage synthesis of the novel compound 1-(1-methyl-5-thiocyanato-1H-pyrrol-2-yl)-3-nitro-1H-1,2,4-triazole utilizing electrochemistry as an environmentally benign tool is reported. The structure of the target molecule was confirmed by 1H and 13C NMR spectroscopy and HRMS. The compound exhibits antibacterial and antifungal activity comparable to chloramphenicol, ciprofloxacin, and fluconazole.
- Open Access
- 7 January 2025
- Published by MDPI AG in Pharmaceuticals
- Vol. 18 (1) , 59
Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control
Background/Objectives: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pharmaceutical substances, focusing on 1-(3-benzoylphenyl)ethanone ketoprofen impurity A (European Pharmacopoeia) as the reference material. Methods: The reference material was synthesised from commercially available acetanilide and benzoyl chloride. The obtained product was purified using preparative chromatography and characterised by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR), and mass spectrometry. The structure was verified using primary research methods to confirm its identity as the target product. Results: The characterisation confirmed the structure and purity of 1-(3-benzoylphenyl)ethanone, achieving a purity of 99.86%, meeting regulatory documentation requirements. The synthesised product was demonstrated to be identical to the target compound and suitable for use as a reference material. Conclusions: The developed method provides a robust approach for the preparation and characterisation of 1-(3-benzoylphenyl)ethanone, enabling its use as a certified reference material in the quality control of medicinal products. This approach ensures compliance with regulatory standards and enhances the reliability of pharmaceutical quality assurance practices.
- 7 January 2025
- Published by MDPI AG in Pharmaceuticals
- Vol. 18 (1) , 59
Open AccessDevelopment of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control
Background/Objectives: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pharmaceutical substances, focusing on 1-(3-benzoylphenyl)ethanone ketoprofen impurity A (European Pharmacopoeia) as the reference material. Methods: The reference material was synthesised from commercially available acetanilide and benzoyl chloride. The obtained product was purified using preparative chromatography and characterised by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR), and mass spectrometry. The structure was verified using primary research methods to confirm its identity as the target product. Results: The characterisation confirmed the structure and purity of 1-(3-benzoylphenyl)ethanone, achieving a purity of 99.86%, meeting regulatory documentation requirements. The synthesised product was demonstrated to be identical to the target compound and suitable for use as a reference material. Conclusions: The developed method provides a robust approach for the preparation and characterisation of 1-(3-benzoylphenyl)ethanone, enabling its use as a certified reference material in the quality control of medicinal products. This approach ensures compliance with regulatory standards and enhances the reliability of pharmaceutical quality assurance practices.