Ekaterina Pyankina
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Ekaterina Pyankina has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Andrey Valerevich Matveev
Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Prospekt, Moscow 119571, Russia
1 shared publication - Ekaterina A. Mikhina
MIREA Russian Technological University, Moscow, Russia
1 shared publication - Ekaterina Mitina
Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, MIREA–Russian Technological University; Moscow 119454, Russia
1 shared publication - Evgeniya S. Oleynik
Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, MIREA–Russian Technological University; Moscow 119454, Russia
1 shared publication
Latest Publications
- Open Access
- 14 November 2024
- Published by MDPI AG in Chemistry Proceedings
- Vol. 16 (1) , 67
New 1,2,4-Triazole Potential Inhibitors of Mycobacterial Imidazoleglycerol-Phosphate Dehydratase (IGPD)
A number of new 5-aminomethyl-1,2,4-triazole-3-carboxamides, demonstrating high model affinity to the IGPD catalytic site comparable with that of the native substrate, were synthesized. The derivatives obtained were tested for antimicrobial potential against M. smegmatis, a species related to M. tuberculosis. During the initial antimicrobial activity evaluation in vitro, some compounds investigated inhibited microbial growth. Moreover, high binding energy values calculated for compounds/enzyme’s catalytic site complexes correlated with the compounds’ antimicrobial efficacy. This suggests that the probable biological action mechanism of new 5-aminomethyl-1,2,4-triazole-3-carboxamides may be based on their binding to the catalytic site of IGPD, which provides prerequisites for further study of this class of compounds as potential IGPD inhibitors.
- 14 November 2024
- Published by MDPI AG in Chemistry Proceedings
- Vol. 16 (1) , 67
Open AccessNew 1,2,4-Triazole Potential Inhibitors of Mycobacterial Imidazoleglycerol-Phosphate Dehydratase (IGPD)
A number of new 5-aminomethyl-1,2,4-triazole-3-carboxamides, demonstrating high model affinity to the IGPD catalytic site comparable with that of the native substrate, were synthesized. The derivatives obtained were tested for antimicrobial potential against M. smegmatis, a species related to M. tuberculosis. During the initial antimicrobial activity evaluation in vitro, some compounds investigated inhibited microbial growth. Moreover, high binding energy values calculated for compounds/enzyme’s catalytic site complexes correlated with the compounds’ antimicrobial efficacy. This suggests that the probable biological action mechanism of new 5-aminomethyl-1,2,4-triazole-3-carboxamides may be based on their binding to the catalytic site of IGPD, which provides prerequisites for further study of this class of compounds as potential IGPD inhibitors.