Eunice Tsang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Eunice Tsang has a total of 19 co-authors. Here are the top co-authors by number of shared publications:
- Andrew Ellis Allen
Microbial and Environmental Genomics Group, J. Craig Venter Institute, La Jolla, CA, USA
2 shared publications - Bethany Cristine Kolody
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA
2 shared publications - Hong Zheng
Microbial and Environmental Genomics Group, J. Craig Venter Institute, La Jolla, CA, USA
2 shared publications - Jillian F. Banfield
Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA
2 shared publications - Rohan Sachdeva
Innovative Genomics Institute, University of California, Berkeley, USA
2 shared publications - Rolf E. Sonnerup
Cooperative Institute for Climate Ocean and Ecosystem Studies University of Washington Seattle WA USA
2 shared publications
Latest Publications
- Open Access
Enzymatic attachment of antigens to probe immune modulation by skin commensals
SUMMARY: The skin colonist Staphylococcus epidermidis induces potent T and B cell responses, which can be redirected against antigens of interest by genetic engineering. However, since many taxa in the microbiome are genetically intractable, the utility of this method is limited. Here, we use recombinant sortase to conjugate antigens to the surface of a wide range of Gram-positive bacterial species, and we show that this non-genetic method can be used to generate protective immunity in vivo.
Open AccessEnzymatic attachment of antigens to probe immune modulation by skin commensals
SUMMARY: The skin colonist Staphylococcus epidermidis induces potent T and B cell responses, which can be redirected against antigens of interest by genetic engineering. However, since many taxa in the microbiome are genetically intractable, the utility of this method is limited. Here, we use recombinant sortase to conjugate antigens to the surface of a wide range of Gram-positive bacterial species, and we show that this non-genetic method can be used to generate protective immunity in vivo.
- 10 July 2025
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 389 (6756) , 176-182
Overturning circulation structures the microbial functional seascape of the South Pacific
Global overturning circulation partitions the deep ocean into regions, each with different physicochemical characteristics, but the extent to which these water masses represent distinct ecosystems remains unknown. In this work, we integrate extensive genomic information with hydrography and water mass age to delineate microbial taxonomic and functional boundaries across the South Pacific. Prokaryotic richness steeply increases with depth in the surface ocean, which forms a so-called phylocline, below which, richness is consistently high, dipping slightly in highly aged water. Reconstructed genomes self-organize into six spatially distinct taxonomic cohorts and 10 functionally distinct biomes that are primarily structured by wind-driven circulation at the surface and density-driven circulation at depth. Overall, water physicochemistry, modulated at depth by water age, drives microbial diversity patterns and functional potential in the pelagic ocean.
- 10 July 2025
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 389 (6756) , 176-182
Overturning circulation structures the microbial functional seascape of the South Pacific
Global overturning circulation partitions the deep ocean into regions, each with different physicochemical characteristics, but the extent to which these water masses represent distinct ecosystems remains unknown. In this work, we integrate extensive genomic information with hydrography and water mass age to delineate microbial taxonomic and functional boundaries across the South Pacific. Prokaryotic richness steeply increases with depth in the surface ocean, which forms a so-called phylocline, below which, richness is consistently high, dipping slightly in highly aged water. Reconstructed genomes self-organize into six spatially distinct taxonomic cohorts and 10 functionally distinct biomes that are primarily structured by wind-driven circulation at the surface and density-driven circulation at depth. Overall, water physicochemistry, modulated at depth by water age, drives microbial diversity patterns and functional potential in the pelagic ocean.
- Open Access
Overturning circulation structures the microbial functional landscape of the South Pacific
Global overturning circulation partitions the deep ocean into regions with unique physicochemical characteristics, but the extent to which these water masses represent distinct ecosystems remains unknown. Here, we integrate extensive genomic information with hydrography and water mass age to delineate microbial taxonomic and functional boundaries across the South Pacific. Prokaryotic richness steeply increases with depth in the surface ocean, forming a "phylocline", below which richness is consistently high, dipping slightly in highly aged water. Reconstructed genomes self-organize into six spatially-distinct taxonomic cohorts and ten functionally-distinct biomes that are primarily structured by wind-driven circulation at the surface and density-driven circulation at depth. Overall, water physicochemistry, modulated at depth by water age, drives microbial diversity and functional potential in the pelagic ocean.
Open AccessOverturning circulation structures the microbial functional landscape of the South Pacific
Global overturning circulation partitions the deep ocean into regions with unique physicochemical characteristics, but the extent to which these water masses represent distinct ecosystems remains unknown. Here, we integrate extensive genomic information with hydrography and water mass age to delineate microbial taxonomic and functional boundaries across the South Pacific. Prokaryotic richness steeply increases with depth in the surface ocean, forming a "phylocline", below which richness is consistently high, dipping slightly in highly aged water. Reconstructed genomes self-organize into six spatially-distinct taxonomic cohorts and ten functionally-distinct biomes that are primarily structured by wind-driven circulation at the surface and density-driven circulation at depth. Overall, water physicochemistry, modulated at depth by water age, drives microbial diversity and functional potential in the pelagic ocean.