Andreea David
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Andreea David has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Annika Wujtschik
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), Halle (Saale), Germany
1 shared publication - Christoph Wagner
Institute of Chemistry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
1 shared publication - Dipendu Dhar
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), Halle (Saale), Germany
1 shared publication - Ismail Ware
Universiti Malaysia Sabah
1 shared publication - Jonas Kappen
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), 06120 Halle (Saale), Germany
1 shared publication - Katrin Franke
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), 06120 Halle (Saale), Germany
1 shared publication
Latest Publications
- Open Access
- 15 January 2025
- Published by Springer Nature in Discover Plants
- Vol. 2 (1) , 1-26
Exploring Hornstedtia scyphifera: an extensive multimethod phytochemical investigation reveals the chemical composition and bioactive potential
Hornstedtia scyphifera (J.Koenig) Steud. represents a lesser-known member of the ginger family (Zingiberaceae) that is used in Malaysia as spice and traditional medicine. The phytochemical investigation of leaves from this species utilizing diverse analytical methods has provided comprehensive insights into its chemical profile for the first time. Headspace gas chromatography-mass spectrometry (HS-GCMS) and GCMS analyses of essential oil and nonpolar extracts verified α-pinene, camphene, p-cymene, and camphor as main volatile compounds. Metabolite profiling of the crude extract by ultra-high-performance-liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) unveiled terpenoids, flavonoids and other phenolics as major compound classes. Isolation and follow-up structure elucidation, involving 1D and 2D NMR, HRMS, UV and CD analysis, yielded two new sesquiterpenoids, (1R,5S,6S,7R,10R)-mustak-14-oic acid (1) and (1R,6S,7S,10R)-6-hydroxy-anhuienosol (2), along with 24 known compounds (seven terpenoids, seven flavonoids, ten phenolics), 21 of these never reported for H. scyphifera. Additionally, the crude extract and fractions from the purification process were screened for antibacterial and antifungal activity. This is supplemented by an extensive literature research for described bioactivities of all isolated compounds. Our results support and explain previously detected antimicrobial, antifungal and neuroprotective effects of H. scyphifera extracts and provide evidence for its potential pharmacological importance.
- 15 January 2025
- Published by Springer Nature in Discover Plants
- Vol. 2 (1) , 1-26
Open AccessExploring Hornstedtia scyphifera: an extensive multimethod phytochemical investigation reveals the chemical composition and bioactive potential
Hornstedtia scyphifera (J.Koenig) Steud. represents a lesser-known member of the ginger family (Zingiberaceae) that is used in Malaysia as spice and traditional medicine. The phytochemical investigation of leaves from this species utilizing diverse analytical methods has provided comprehensive insights into its chemical profile for the first time. Headspace gas chromatography-mass spectrometry (HS-GCMS) and GCMS analyses of essential oil and nonpolar extracts verified α-pinene, camphene, p-cymene, and camphor as main volatile compounds. Metabolite profiling of the crude extract by ultra-high-performance-liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) unveiled terpenoids, flavonoids and other phenolics as major compound classes. Isolation and follow-up structure elucidation, involving 1D and 2D NMR, HRMS, UV and CD analysis, yielded two new sesquiterpenoids, (1R,5S,6S,7R,10R)-mustak-14-oic acid (1) and (1R,6S,7S,10R)-6-hydroxy-anhuienosol (2), along with 24 known compounds (seven terpenoids, seven flavonoids, ten phenolics), 21 of these never reported for H. scyphifera. Additionally, the crude extract and fractions from the purification process were screened for antibacterial and antifungal activity. This is supplemented by an extensive literature research for described bioactivities of all isolated compounds. Our results support and explain previously detected antimicrobial, antifungal and neuroprotective effects of H. scyphifera extracts and provide evidence for its potential pharmacological importance.