Aniela-Roxana Nodiți-Cuc

Background/Objectives: Disordered eating behaviours are increasingly common among young adults, yet nutrition-focused, region-specific data from Romania and Central and Eastern Europe (CEE) remain scarce. We characterised nutritional patterns, weight-control practices, disordered-eating indicators, body image, and psychosocial factors among Romanian young adults and tested how these differed across body mass index (BMI) categories. Methods: In a cross-sectional online survey (March–April 2026), 753 Romanian adults aged 18–30 years (93.5% female) completed a 30-item questionnaire. Self-reported anthropometric measurements were classified using WHO BMI cutoffs. Prevalences (with Wilson 95% confidence intervals [CIs]) were compared across BMI categories using the chi-square test, and multivariable logistic regression, adjusted for age and sex, estimated odds ratios (ORs). Results: Most participants were normal weight (59.1%); 11.6% were underweight, 29.3% were overweight or obese, and 86.3% were omnivorous. Dietary restriction (57.4%) and physical exercise (46.7%) were the leading weight-control methods; self-induced vomiting (6.4%) and medication (4.5%) were less frequent. Lifetime compulsive/emotional eating was reported by 50.1%, current stress-related eating by 49.1%, and guilt after eating by 66.1%. Lifetime night eating reached 31.9% (current, 12.9%). Body dissatisfaction (36.1% “not at all satisfied”), difficulty looking in the mirror (66.7%) and self-reported stress (82.2%) were widespread. In adjusted models, dietary restriction, emotional eating and guilt after eating rose steeply and monotonically with BMI (overweight/obesity vs. normal weight: aOR 2.34, 2.49 and 2.73, respectively; all p < 0.001), whereas current night eating and frequent self-weighing did not differ across BMI categories (p = 0.92 and p = 0.82). Dietary restriction increased from 24.1% in underweight to 55.5% in normal-weight and 74.2% in overweight/obesity participants; corresponding gradients were also observed for emotional eating and food-related guilt. Conclusions: In this predominantly female, largely urban online convenience sample of Romanian young adults, self-reported behavioural risk indicators related to disordered eating were common. Restriction, emotional eating and food-related guilt increased with BMI, whereas night eating and self-weighing showed no clear BMI gradient. These findings should be interpreted cautiously and should not be generalised to Romanian young men or rural populations without confirmation in more representative samples.

Background: Glioblastoma (used to be called glioblastoma multiforme—GBM) is the most common and aggressive brain tumor, having the lowest overall survival rate. Initial focal neurological deficits are primarily attributable to surrounding edema; however, as tumor invasion progresses, these deficits become more pronounced and permanent. The standard treatment for newly diagnosed glioblastoma is represented by cytoreductive neurosurgery followed by the Stupp Protocol. Postoperative recovery of the patient with glioblastoma is a long-term process that should include, for overall more acceptable outcomes, neurorehabilitation. This review aims to bring together evidence from neuro-oncology, neurosurgery, and neurorehabilitation in order to better understand the factors associated with recovery, functional status, and quality of life (QoL) after glioblastoma surgery. Our work also aimed to update the related knowledge base and to attempt to optimize the related protocols in patients with operated cerebral glioblastoma. Methods: For these purposes, we conducted a systematic literature review to assess the current state of research referring to the above-mentioned topic. We have used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA—widely recognized internationally) methodology. We used, in this respect, specific keyword combinations/“syntaxes” for searching literature in the domain, in four international databases. Results: Following PRISMA screening, 14 studies met the predefined eligibility criteria. Additional manual reference screening and complementary searches identified further relevant publications, resulting in a total of 22 included articles. Together, the reviewed work addressed a diverse range of topics relevant to postoperative glioblastoma management, including the potential role of multidisciplinary rehabilitation, cognitive interventions, neuromodulation approaches, and functional assessment strategies in improving postoperative outcomes and QoL in glioblastoma patients, while emphasizing that this interdisciplinary domain warrants more extended approaches. Discussion and Conclusions: Despite the relatively limited and largely exploratory available information, neurorehabilitation may contribute to improved functional outcomes and QoL in patients with glioblastoma.

Background: The rapid evolution of dental adhesive systems presents both opportunities and challenges for clinical practice, particularly regarding the translation of emerging evidence into routine use. Aim: This study aimed to assess the knowledge, attitudes, and self-reported practices related to modern adhesive systems among Romanian dentists and to explore factors associated with their clinical decision-making. Materials and Methods: An observational cross-sectional study was conducted between November 2025 and February 2026 using a 115-item online questionnaire. A convenience sample of 372 Romanian dentists participated. Statistical analysis included descriptive statistics, chi-square and Kruskal–Wallis tests, and multivariate models (multiple linear regression, binary logistic regression, and multinomial logistic regression). Internal consistency of the knowledge scale was assessed using Cronbach’s alpha. Results: The knowledge scale demonstrated good reliability (Cronbach’s α = 0.873). Although 68.0% of respondents reported familiarity with universal adhesives, a discrepancy between awareness and reported clinical application was observed for several key concepts, including MMP inhibitors and hydrolytic stability. Notably, 14.8% of participants were unaware whether their preferred adhesive system contained 10-MDP. Continuing education frequency was the only independent predictor of higher knowledge scores (β = 1.63, p = 0.024), while greater clinical experience was inversely associated with rubber dam use (OR = 0.550, p = 0.024). Conclusions: The findings suggest a discrepancy between theoretical knowledge and the clinical implementation of modern adhesive concepts. Structured continuing education plays a critical role in improving knowledge and may help bridge this gap in clinical practice.

Background/Objectives: Diet is a primary and modifiable determinant of gut microbiota composition, diversity, and metabolic activity, thereby shaping microbial-derived metabolites, immune and inflammatory signalling, neuroendocrine regulation, and neural communication with the central nervous system. Western dietary patterns, characterised by high intake of ultra-processed foods, saturated fats, and low dietary fibre, are consistently associated with gut dysbiosis, impaired intestinal barrier function, chronic low-grade inflammation, and increased risk of depression, anxiety, cognitive impairment, and neurodegenerative disorders. Methods: This narrative review synthesises evidence from human observational studies, randomised controlled trials, animal models, and mechanistic investigations examining interactions among diet, gut microbiota, and mental health or neurobiological outcomes. Literature searches were conducted in PubMed, Scopus, and Web of Science for articles published up to December 2025. Results: The study highlights the therapeutic potential and limitations of dietary interventions, prebiotics, probiotics, and psychobiotics, and critically evaluates them. Also facilitates an improved understanding of diet–microbiome–brain interactions, which may help the development of personalised, nutrition-based strategies integrated into mental health prevention and clinical care. Conclusions: These findings support diet-based, microbiome-informed strategies as scalable adjuncts in mental health prevention and care.

Background: Melanoma remains a leading cause of cancer-related mortality, with early detection being the primary determinant of survival. The emergence of MLLMs offers a potential paradigm shift in accessible screening. However, the diagnostic reliability and safety of these general-purpose models in oncology remain insufficiently characterized. Methods: This study performed a head-to-head comparison of GPT-5, Gemini 3, and Grok 4 to evaluate their efficacy as first-level screening tools for cutaneous melanoma. A retrospective analysis was conducted using a balanced dataset of 100 clinical images (50 histopathologically confirmed benign, 50 malignant) from the ISIC archive. Results: Gemini 3 achieved the highest overall accuracy (71%) and specificity (94%), while Grok 4 demonstrated the highest sensitivity (52%). All models exhibited a critical deficit in sensitivity, missing approximately half of the malignant lesions. Statistical testing revealed no significant performance differences between the models (p > 0.05). Notably, Gemini 3 exhibited severe overconfidence, maintaining a high CI (84.62%) even during false-negative predictions, whereas GPT-5 and Grok 4 showed better calibration with a significant drop in confidence upon incorrect diagnosis. Conclusions: While current MLLMs possess a foundational capacity for dermatological analysis, their unacceptably low sensitivity and potential for overconfident misdiagnosis render them unsafe as standalone screening tools. At present, MLLMs should only be utilized as complementary tools under strict clinical supervision.

Universities play a strategic role in advancing the Sustainable Development Goals (SDGs) through community engagement, particularly within medical education. This study examines medical students’ involvement in volunteering activities and evaluates how such engagement contributes to SDG 3 (Good Health and Well-being) and SDG 4 (Quality Education). A cross-sectional survey was conducted among 499 students from the Victor Babeș University of Medicine and Pharmacy in Timișoara, using a structured questionnaire assessing perceived community impact, soft skills development, motivation for volunteering, sustainability orientation, and institutional support. Results indicate a high level of availability and prior participation in volunteering, reflecting strong internalization of public health and social responsibility values. While no significant differences were observed between volunteers and non-volunteers regarding perceived community impact (SDG 3), volunteer experience was significantly associated with higher levels of soft skills development and motivation (SDG 4). Strong positive correlations were identified between perceived community impact and motivational, educational, and sustainability related dimensions. The intensity of involvement was modestly associated with sustainability orientation and institutional support. Despite high motivation, students reported limited structured institutional frameworks for sustained engagement. The findings suggest that medical volunteering functions as a dual mechanism, strengthening professional competencies while reinforcing community health orientation. Institutionalizing structured outreach programs, particularly in underserved areas, could enhance long-term impact and align medical education more effectively with the 2030 Sustainable Development Agenda.

Introduction: Implant-based breast reconstruction is associated with an increased risk of ischemic complications, which may result in implant loss, suboptimal aesthetic outcomes, and delays in adjuvant oncological treatment. Additionally, axillary surgery carries a risk of upper-limb lymphedema. Indocyanine green (ICG) angiography enables more accurate real-time assessment of tissue perfusion than clinical evaluation alone, while axillary reverse mapping (ARM) facilitates the preservation of upper-limb lymphatics. The integration of these techniques reduces complications and improves both functional and aesthetic outcomes. Materials and methods: A total of 208 breast cancer patients who underwent mastectomy followed by immediate implant-based breast reconstruction were enrolled in this case–control study. The prospective intervention group received intraoperative ICG angiography at three time points and underwent ARM with ICG. Conventional surgical techniques were applied in the retrospective control group. Results: ICG angiography showed excellent diagnostic accuracy for predicting postoperative ischemic complications (AUC = 0.93, 95% CI 0.82–0.99, p < 0.001). Compared with the control group, patients in the ICG group had significantly lower rates of mastectomy skin flap necrosis (11.5% vs. 30.8%, p = 0.001), seroma (4.8% vs. 14.4%, p = 0.032), hematoma (1.9% vs. 9.6%, p = 0.033), and lymphedema (2.9% vs. 17.3%, p < 0.001). They also experienced shorter hospitalization (6.2 ± 1.9 vs. 8.0 ± 2.8 days, p < 0.001), fewer delays in adjuvant treatment initiation (16.3% vs. 32.7%, p = 0.010), and higher aesthetic satisfaction scores (81.41 ± 10.12 vs. 76.03 ± 9.74, p <0.001). Conclusions: Intraoperative indocyanine green angiography is a valuable tool for predicting ischemic complications in alloplastic breast reconstruction and is associated with reduced morbidity, fewer delays in adjuvant treatment, and improved aesthetic outcomes. Preliminary evidence suggests that axillary reverse mapping is associated with lower rates of upper-limb lymphedema.

Context: The increasing incidence of secondary caries and the failure of restorations have intensified research into dental restorative materials capable of actively interacting with the oral environment. In this context, antibacterial and bioregenerative nanomaterials have attracted growing scientific interest due to their potential to inhibit biofilm formation while simultaneously supporting mineral repair processes. Objective: This narrative review analyzes recent developments in nanostructured materials for restorative dentistry and oral health applications, with particular emphasis on antibacterial agents, bioactive systems, and emerging dual-function approaches that integrate multiple biological functions into restorative materials. Scope of the Review: The analyzed literature indicates that metallic nanoparticles, cationic monomers, and natural nanopolymers can reduce bacterial adhesion and metabolic activity under experimental conditions. In parallel, bioactive nanomaterials such as nanohydroxyapatite, bioactive glass, and calcium phosphate-based systems have demonstrated the ability to release remineralizing ions and to promote mineral deposition at the tooth–material interface. Dual-function hybrid materials aim to combine these antibacterial and bioregenerative effects within a single restorative system. Interpretative Perspective: Despite these advances, most available evidence derives from in vitro and preclinical studies, with significant heterogeneity across experimental models, evaluation methods, and outcome variables. This variability limits direct comparisons between studies and necessitates a cautious interpretation of claims regarding long-term antibacterial efficacy, functional tissue regeneration, and routine clinical applicability. Conclusions: Antibacterial and bioregenerative nanomaterials represent a relevant and continuously evolving research direction in restorative dentistry. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility.

Background: As technology continues to shape society, younger generations are increasingly accustomed to its integration into daily life, making it mandatory for medical educators to adopt innovative tools like virtual reality (VR). This systematic review examines the efficacy of VR in obstetric training and patient care, focusing on its impact on educational engagement, procedural skill acquisition, and pain management in obstetric patients. Methods: A systematic review of the current literature was conducted using databases: PubMed, Web of Science, Science Direct, Scopus, Embase, The Cochrane Library, and Clinicaltrials.gov analyzing randomized controlled studies on VR’s use in obstetric training and patient care. Inclusion criteria focused on studies evaluating VR’s role in enhancing clinical skills, and pain and anxiety management during labor and procedures. Only randomized controlled trials published in English were considered. The risk of bias was assessed using RoB 2 for RCTs. Data extraction and quality appraisal were performed independently by two reviewers. Results: A total of 18 studies met the inclusion criteria. Among them, 13 studies focused on VR for pain relief and anxiety reduction, and 5 studies on medical training and skill acquisition. Most studies used immersive VR headsets, while some utilized interactive VR or serious gaming platforms. Adverse effects such as motion sickness and visual discomfort were reported in a few cases but did not significantly impact participant engagement. Conclusions: VR holds the potential to improve obstetric training and patient care by aligning with the learning preferences of younger generations and enhancing both educational and patient care experiences. However, heterogeneity in sample sizes, participants, and intervention types limits generalizability. Further large-scale, high-quality RCTs are needed to validate findings and standardize VR applications in obstetrics. This review was registered in PROSPERO (Registration ID: CRD42024619197).

Endometriosis is characterized by alterations of the action and control mechanisms that lead to the development of ectopic endometrial tissue. This study aimed to analyze the molecular profile of ectopic endometrium by evaluating the expression of several biomarkers [estrogen receptor (ER), progesterone receptor (PR), anti-apoptotic protein Bcl-2, and Ki-67 antigen] in relation to the stage of the disease and symptoms. A prospective study over a period of one year, consisting of 14 patients with endometriosis, was performed. All patients received laparoscopic surgical treatment for excision of the lesions and staging of the disease. The expression of the aforementioned biomarkers was assessed in the ectopic endometrial tissue from the excised lesions using immunohistochemistry to determine their expression in the glandular epithelium and stroma. The mean expression of biomarkers in the epithelial and stromal levels did not differ significantly based on disease stage. Epithelial ER expression was significantly positively correlated with stromal ER, epithelial PR, and stromal PR. Stromal ER was significantly positively correlated with epithelial PR and stromal Ki-67. Epithelial Bcl-2 was significantly positively correlated with stromal Bcl-2. Epithelial Ki-67 was significantly positively correlated with stromal Ki-67. Finally, epithelial Bcl-2 expression was significantly positively correlated with the intensity of dyspareunia. The correlation between epithelial Bcl-2 expression and the intensity of dyspareunia highlights a potential molecular link to the severity of symptoms in endometriosis. These results suggest that further exploration of these biomarkers could lead to improved understanding of their clinical implications and more personalized therapies for patients with endometriosis.