Janis Seibt
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Janis Seibt has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Emma-Luise Kulzer
Research Campus STIMULATE, Otto-von-Guericke-University Magdeburg, 39106 Magdeburg, Germany
1 shared publication - Georg Rose
Otto-von-Guericke-University Magdeburg
1 shared publication - Ivan Vogt
Research Campus STIMULATE, Otto von Guericke University Magdeburg, Magdeburg, Germany
1 shared publication - Maciej Pech
Research Campus STIMULATE, University of Magdeburg, Otto-Hahn-Straße 2, 39106, Magdeburg, Saxony-Anhalt, Germany
1 shared publication - Martin Volk
Department of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-von-Guericke University, 39120 Magdeburg, Germany
1 shared publication - Oliver Stephan Grosser
Research Campus STIMULATE, University of Magdeburg, Otto-Hahn-Straße 2, 39106, Magdeburg, Saxony-Anhalt, Germany
1 shared publication
Latest Publications
- Open Access
- 10 February 2025
- Published by MDPI AG in Bioengineering
- Vol. 12 (2) , 171
Microwave-Assisted Optimization of Polyvinyl Alcohol Cryogel (PVA-C) Manufacturing for MRI Phantom Production
Objectives: Anthropomorphic phantoms offer a promising solution to minimize animal testing, enable medical training, and support the efficient development of medical devices. The adjustable mechanical, biochemical, and imaging properties of the polyvinyl alcohol cryogel (PVA-C) make it an appropriate phantom material for mimicking soft tissues. Conventional manufacturing (CM) of aqueous solutions requires constant stirring, using a heated water bath, and monitoring. Methods: To explore potential improvements in the dissolution of PVA crystals in water, a microwave-based manufacturing method (MWM) was employed. Samples created using CM and MWM (n = 14 each) were compared. Because PVA-C is a multifunctional phantom material (e.g., in magnetic resonance imaging (MRI)), its MRI properties (T1/T2 relaxation times) and elasticity were determined. Results: T1 relaxation times did not significantly differ between the two methods (p = 0.3577), whereas T2 and elasticity for the MWM were significantly higher than those for the CM (p < 0.001). The MWM reduced the production time by 11% and decreased active user involvement by 93%. Conclusions: The MWM offers a promising, easily implementable, and time-efficient method for manufacturing PVA-C-based phantoms. Nevertheless, manufacturing-related microstructural properties and sample molding require further study.
- 10 February 2025
- Published by MDPI AG in Bioengineering
- Vol. 12 (2) , 171
Open AccessMicrowave-Assisted Optimization of Polyvinyl Alcohol Cryogel (PVA-C) Manufacturing for MRI Phantom Production
Objectives: Anthropomorphic phantoms offer a promising solution to minimize animal testing, enable medical training, and support the efficient development of medical devices. The adjustable mechanical, biochemical, and imaging properties of the polyvinyl alcohol cryogel (PVA-C) make it an appropriate phantom material for mimicking soft tissues. Conventional manufacturing (CM) of aqueous solutions requires constant stirring, using a heated water bath, and monitoring. Methods: To explore potential improvements in the dissolution of PVA crystals in water, a microwave-based manufacturing method (MWM) was employed. Samples created using CM and MWM (n = 14 each) were compared. Because PVA-C is a multifunctional phantom material (e.g., in magnetic resonance imaging (MRI)), its MRI properties (T1/T2 relaxation times) and elasticity were determined. Results: T1 relaxation times did not significantly differ between the two methods (p = 0.3577), whereas T2 and elasticity for the MWM were significantly higher than those for the CM (p < 0.001). The MWM reduced the production time by 11% and decreased active user involvement by 93%. Conclusions: The MWM offers a promising, easily implementable, and time-efficient method for manufacturing PVA-C-based phantoms. Nevertheless, manufacturing-related microstructural properties and sample molding require further study.