Sangmin Lee
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Sangmin Lee has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Myunghoo Kim
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul, Korea
1 shared publication - Seon Beom Kim
Department of Food Science and Technology, Pusan National University, Miryang 50463, Republic of Korea
1 shared publication - Sun Young Park
Research Institute of Human Ecology, Yeungnam University, Gyeongsan-si, Republic of Korea
1 shared publication - Tae Hwan Oh
School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea
1 shared publication - Young Ho Seo
Institute for Future Earth, Pusan National University, Busan 46241, Republic of Korea
1 shared publication
Latest Publications
- Open Access
PVA/Gelatin/Cnidium monnieri Composite Scaffolds for Atopic Dermatitis Skin Tissue Regeneration
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by impaired barrier function and persistent inflammation, necessitating advanced therapeutic solutions. This study presents the development of a novel composite hydrogel scaffold composed of polyvinyl alcohol (PVA), gelatin, and Cnidium monnieri (CM) extract, designed to address the dual challenges of tissue regeneration and inflammation suppression. Fabricated via optimized freeze–thaw crosslinking and lyophilization, the scaffold exhibited a highly porous structure conducive to enhanced cell proliferation and controlled bioactive release. FT-IR analysis confirmed robust intermolecular interactions among PVA, gelatin, and CM bioactives, while SEM imaging revealed a well-developed porous network. The UPLC analysis demonstrated the sustained release of key CM compounds, such as osthole and imperatorin, which contributed to the scaffold’s anti-inflammatory properties. Biological assessments using HaCaT keratinocytes under inflammatory conditions induced by TNF-α and IFN-γ revealed improved cell viability and significant suppression of IL-8 expression, a critical marker in AD-related inflammation. These findings underscore the potential of the PVA/Gel/CM composite hydrogel as an advanced therapeutic platform for inflammatory skin disorders.
Open AccessPVA/Gelatin/Cnidium monnieri Composite Scaffolds for Atopic Dermatitis Skin Tissue Regeneration
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by impaired barrier function and persistent inflammation, necessitating advanced therapeutic solutions. This study presents the development of a novel composite hydrogel scaffold composed of polyvinyl alcohol (PVA), gelatin, and Cnidium monnieri (CM) extract, designed to address the dual challenges of tissue regeneration and inflammation suppression. Fabricated via optimized freeze–thaw crosslinking and lyophilization, the scaffold exhibited a highly porous structure conducive to enhanced cell proliferation and controlled bioactive release. FT-IR analysis confirmed robust intermolecular interactions among PVA, gelatin, and CM bioactives, while SEM imaging revealed a well-developed porous network. The UPLC analysis demonstrated the sustained release of key CM compounds, such as osthole and imperatorin, which contributed to the scaffold’s anti-inflammatory properties. Biological assessments using HaCaT keratinocytes under inflammatory conditions induced by TNF-α and IFN-γ revealed improved cell viability and significant suppression of IL-8 expression, a critical marker in AD-related inflammation. These findings underscore the potential of the PVA/Gel/CM composite hydrogel as an advanced therapeutic platform for inflammatory skin disorders.