Xue Su
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Xue Su has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Lan Hao Liu
School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China
1 shared publication - Mingyue Che
School of Marine Science and Engineering, Qingdao Agricultural University, 700 Greatwall Road, Qingdao 266109, China
1 shared publication - Pin Nie
School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China
1 shared publication - Su Wang
Laboratory of Comparative Immunology, School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, China
1 shared publication - Xiu Feng Han
School of Marine Science and Engineering, Qingdao Agricultural University, 700 Greatwall Road, Qingdao 266109, China
1 shared publication
Latest Publications
- Open Access
Identification and Expression Analyses of IL-17/IL-17R Gene Family in Snakehead (Channa argus) Following Nocardia seriolae Infection
Background/Objectives: The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction. Methods: This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads. Results: A duplication event occurred in snakehead IL-17s and IL-17Rs, but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that IL-17s/IL-17Rs were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon Nocardia seriolae stimulation, most members were expressed, particularly IL-17C2, IL-17D, IL-17N, IL-17RA1, IL-17RA2, IL-17RC1, and IL-17RE1, which were significantly upregulated in gill and intestine. Conclusions: These results suggested that IL-17s and IL-17Rs played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture.
Open AccessIdentification and Expression Analyses of IL-17/IL-17R Gene Family in Snakehead (Channa argus) Following Nocardia seriolae Infection
Background/Objectives: The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction. Methods: This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads. Results: A duplication event occurred in snakehead IL-17s and IL-17Rs, but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that IL-17s/IL-17Rs were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon Nocardia seriolae stimulation, most members were expressed, particularly IL-17C2, IL-17D, IL-17N, IL-17RA1, IL-17RA2, IL-17RC1, and IL-17RE1, which were significantly upregulated in gill and intestine. Conclusions: These results suggested that IL-17s and IL-17Rs played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture.