Mengyuan Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Interests
Mengyuan Chen has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Canxia He
School of Public Health, Health Science Center, Ningbo University, Ningbo, Zhejiang, PR China
2 shared publications - Jingyi Ren
School of Public Health, Health Science Center, Ningbo University, Ningbo 315211, China
2 shared publications - Gejun Yu
School of Public Health, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China, China
1 shared publication - Gejun Yu
School of Public Health, Health Science Center, Ningbo University, Ningbo 315211, China
1 shared publication - Wentao Wu
School of Public Health, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China, China
1 shared publication - Wentao Wu
School of Public Health, Health Science Center, Ningbo University, Ningbo 315211, China
1 shared publication
Latest Publications
- Open Access
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing a significant global health burden. Recent studies highlight the critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC’s pathogenesis. The relationship between BAs and gut microbiota is bidirectional: microbiota influence BA composition, while BAs regulate microbiota diversity and activity through receptors like Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Targeting bile-acid metabolism to reshape gut microbiota presents a promising therapeutic strategy for UC. This review examines the classification and synthesis of BAs, their interactions with gut microbiota, and the potential of nutritional and microbial interventions. By focusing on these therapies, we aim to offer innovative approaches for effective UC management.
Open AccessTargeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing a significant global health burden. Recent studies highlight the critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC’s pathogenesis. The relationship between BAs and gut microbiota is bidirectional: microbiota influence BA composition, while BAs regulate microbiota diversity and activity through receptors like Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Targeting bile-acid metabolism to reshape gut microbiota presents a promising therapeutic strategy for UC. This review examines the classification and synthesis of BAs, their interactions with gut microbiota, and the potential of nutritional and microbial interventions. By focusing on these therapies, we aim to offer innovative approaches for effective UC management.
- Open Access
- 27 February 2025
- Published by MDPI AG in Preprints.org
Targeting Bile Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing a significant global health burden. Recent studies highlight the critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC’s pathogenesis. The relationship between BAs and gut microbiota is bidirectional: microbiota influence BA composition, while BAs regulate microbiota diversity and activity through receptors like Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Targeting bile acid metabolism to reshape gut microbiota presents a promising therapeutic strategy for UC. This review examines the classification and synthesis of BAs, their interactions with gut microbiota, and the potential of nutritional and microbial interventions. By focusing on these therapies, we aim to offer innovative approaches for effective UC management.
- 27 February 2025
- Published by MDPI AG in Preprints.org
Open AccessTargeting Bile Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing a significant global health burden. Recent studies highlight the critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC’s pathogenesis. The relationship between BAs and gut microbiota is bidirectional: microbiota influence BA composition, while BAs regulate microbiota diversity and activity through receptors like Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Targeting bile acid metabolism to reshape gut microbiota presents a promising therapeutic strategy for UC. This review examines the classification and synthesis of BAs, their interactions with gut microbiota, and the potential of nutritional and microbial interventions. By focusing on these therapies, we aim to offer innovative approaches for effective UC management.