Marisol Macarena Palominos-Rivera

Demographic and clinical characteristics of the UPCA referral cohort.

Multimodal artificial intelligence (MMAI) biomarker score distribution by A) NCCN and B) CAPRA risk groups.

Univariable analyses of multimodal artificial intelligence (MMAI) score for biochemical recurrence (BCR) and adverse pathology (AP) at radical prostatectomy within NCCN Subgroup.

Comparison of multimodal artificial intelligence (MMAI) score to individual clinical variables, NCCN risk groups, and CAPRA score.

Demographic and clinical characteristics of the UPCA referral cohort.

Univariable analyses of multimodal artificial intelligence (MMAI) score for biochemical recurrence (BCR) and adverse pathology (AP) at radical prostatectomy within NCCN Subgroup.

Purpose:A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, and T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of men who underwent radical prostatectomy (RP) for localized prostate cancer at a tertiary referral center in Sweden.Experimental Design:Association between the MMAI scores (continuous and categorical) and endpoints of interest was assessed with Fine–Gray and cumulative incidence analyses for biochemical recurrence (BCR) and logistic regression for adverse pathology (AP) at RP.Results:The analysis included 143 patients with evaluable biopsy pathology images and complete clinical data to generate MMAI scores. The median follow-up was 8.8 years. At diagnosis, the median PSA was 7.5 ng/mL, the median age was 64 years, 29% had a Gleason grade group ≥3, and 88 men were evaluable for AP at RP. MMAI was significantly associated with BCR [subdistribution HR, 2.45; 95% confidence interval (CI), 1.77–3.38; P < 0.001] and AP at RP (OR, 4.85; 95% CI, 2.54–10.78; P < 0.001). Estimated 5-year BCR rates for MMAI intermediate to high versus low were 25% (95% CI, 16%–36%) versus 4% (95% CI, 1%–11%), respectively.Conclusions:The MMAI biomarker, previously shown to be prognostic for distant metastasis and prostate cancer–specific mortality in men receiving definitive radiation, was prognostic for post-RP endpoints: BCR and AP. This biomarker validation study further supports the use of MMAI biomarkers in men with prostate cancer outside North America and those treated with RP.

Multimodal artificial intelligence (MMAI) biomarker score distribution by A) NCCN and B) CAPRA risk groups.

Comparison of multimodal artificial intelligence (MMAI) score to individual clinical variables, NCCN risk groups, and CAPRA score.

Purpose: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, and T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of men who underwent radical prostatectomy (RP) for localized prostate cancer at a tertiary referral center in Sweden. Experimental Design: Association between the MMAI scores (continuous and categorical) and endpoints of interest was assessed with Fine–Gray and cumulative incidence analyses for biochemical recurrence (BCR) and logistic regression for adverse pathology (AP) at RP. Results: The analysis included 143 patients with evaluable biopsy pathology images and complete clinical data to generate MMAI scores. The median follow-up was 8.8 years. At diagnosis, the median PSA was 7.5 ng/mL, the median age was 64 years, 29% had a Gleason grade group ≥3, and 88 men were evaluable for AP at RP. MMAI was significantly associated with BCR [subdistribution HR, 2.45; 95% confidence interval (CI), 1.77–3.38; P < 0.001] and AP at RP (OR, 4.85; 95% CI, 2.54–10.78; P < 0.001). Estimated 5-year BCR rates for MMAI intermediate to high versus low were 25% (95% CI, 16%–36%) versus 4% (95% CI, 1%–11%), respectively. Conclusions: The MMAI biomarker, previously shown to be prognostic for distant metastasis and prostate cancer–specific mortality in men receiving definitive radiation, was prognostic for post-RP endpoints: BCR and AP. This biomarker validation study further supports the use of MMAI biomarkers in men with prostate cancer outside North America and those treated with RP.