Lexie W. Q. Xi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Lexie W. Q. Xi has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Dawn Jing Hui Neo
Singapore Eye Research Institute, Singapore 169856, Singapore
1 shared publication - Evelyn King Fai Yim
Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
1 shared publication - Fancheng Sun
Department of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, Canada
1 shared publication - Gary Swee Lim Peh
Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore
1 shared publication - Jodhbir Singh Mehta
Regenerative Therapy Research Group, Singapore Eye Research Institute, Singapore 169856, Singapore
1 shared publication - Myagmartsend Enkhbat
Department of Biomedical Engineering Shanghai Jiao Tong University Shanghai China
1 shared publication
Latest Publications
- Open Access
Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy
Fuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal transplantation globally. Currently, there is no clearly defined canonical pathway for this disease, and it has been proposed that the combinatorial effects of genetic mutations and exogenous factors cause FECD. Clinical studies and observations have provided valuable knowledge and understanding of FECD, while preclinical studies are essential for gaining insights into disease progression and mechanisms for the development and testing of regenerative medicine therapies. In this review, we first introduce the proposed genetic and molecular pathologies of FECD. Notably, we discuss the impact of abnormal extracellular matrix deposition (guttata), endothelial-to-mesenchymal transition, cell senescence, and oxidative stress on the pathology and etiology of FECD. We review and summarize the in vitro cell models, ex vivo tissues, and in vivo animal models used to study FECD. The benefits and challenges of each model are also discussed.
Open AccessPreclinical Models for Studying Fuchs Endothelial Corneal Dystrophy
Fuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal transplantation globally. Currently, there is no clearly defined canonical pathway for this disease, and it has been proposed that the combinatorial effects of genetic mutations and exogenous factors cause FECD. Clinical studies and observations have provided valuable knowledge and understanding of FECD, while preclinical studies are essential for gaining insights into disease progression and mechanisms for the development and testing of regenerative medicine therapies. In this review, we first introduce the proposed genetic and molecular pathologies of FECD. Notably, we discuss the impact of abnormal extracellular matrix deposition (guttata), endothelial-to-mesenchymal transition, cell senescence, and oxidative stress on the pathology and etiology of FECD. We review and summarize the in vitro cell models, ex vivo tissues, and in vivo animal models used to study FECD. The benefits and challenges of each model are also discussed.