Isabel F. van der Poel
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Isabel F. van der Poel has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Anke-Hilse Maitland-Van der Zee
Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
1 shared publication - Annabel S. Zaat
Faculty of Medicine, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
1 shared publication - Bart E. van Ewijk
Department of Paediatric Medicine, Tergooi Medical Centre, 1201 DA Hilversum, The Netherlands
1 shared publication - Berber Kapitein
Pediatric Intensive Care Unit, Emma Children's Hospital, AmsterdamUniversity Medical Center, Amsterdam, The Netherlands.
1 shared publication - Claudia Gagliani
PROMISE Department, Division of Respiratory Medicine, University of Palermo, 90127 Palermo, Italy
1 shared publication - Fleur L. Sondaal
Faculty of Medicine, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
1 shared publication
Latest Publications
- Open Access
- 3 April 2025
- Published by MDPI AG in Metabolites
- Vol. 15 (4) , 247
Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis
Background: Severe acute asthma (SAA) in children can be life-threatening. There has been a significant rise in paediatric intensive care unit (PICU) admissions due to SAA over the past two decades. While asthma is a heterogeneous disease, its underlying pathophysiological pathways remain underexplored. This study aimed to assess the value of non-invasive targeted exhaled breath metabolomics analysis to better characterise SAA. Methods: Breath samples from 17 children admitted to the PICU with SAA (cases) and 27 children with controlled severe asthma (controls) were analysed using thermal desorption gas chromatography–mass spectrometry (TD-GC-MS). Results: A targeted volatile organic compound (VOC) analysis identified 25 compounds, of which 16 were shared between groups. Four VOCs were significantly more often present in SAA, and nine VOCs exhibited higher concentrations in SAA. Longitudinal analysis of VOCs from follow-up samples of 10 cases showed no significant temporal differences, reinforcing the reproducibility of identified biomarkers. Conclusions: This study exemplifies the potential of exhaled breath analysis to provide insights into the molecular background of SAA. Breath metabolomics may enable early recognition of severe asthma attacks and preventive therapeutic interventions in children with severe asthma.
- 3 April 2025
- Published by MDPI AG in Metabolites
- Vol. 15 (4) , 247
Open AccessUncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis
Background: Severe acute asthma (SAA) in children can be life-threatening. There has been a significant rise in paediatric intensive care unit (PICU) admissions due to SAA over the past two decades. While asthma is a heterogeneous disease, its underlying pathophysiological pathways remain underexplored. This study aimed to assess the value of non-invasive targeted exhaled breath metabolomics analysis to better characterise SAA. Methods: Breath samples from 17 children admitted to the PICU with SAA (cases) and 27 children with controlled severe asthma (controls) were analysed using thermal desorption gas chromatography–mass spectrometry (TD-GC-MS). Results: A targeted volatile organic compound (VOC) analysis identified 25 compounds, of which 16 were shared between groups. Four VOCs were significantly more often present in SAA, and nine VOCs exhibited higher concentrations in SAA. Longitudinal analysis of VOCs from follow-up samples of 10 cases showed no significant temporal differences, reinforcing the reproducibility of identified biomarkers. Conclusions: This study exemplifies the potential of exhaled breath analysis to provide insights into the molecular background of SAA. Breath metabolomics may enable early recognition of severe asthma attacks and preventive therapeutic interventions in children with severe asthma.