Ke Guo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Ke Guo has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Jing Zhang
State Key Laboratory for Quality Ensurance and Sustainable Use of Daodi Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China
1 shared publication - Peng Sun
China Academy Of Chinese Medical Sciences
1 shared publication - Shuaichen Zhang
State Key Laboratory for Quality Ensurance and Sustainable Use of Daodi Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China
1 shared publication - Xiaoqiang Chang
School of Pharmacy, Bengbu Medical University, Bengbu 233000, China
1 shared publication - Yu Ren
Yunnan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, Yunnan, China; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
1 shared publication
Latest Publications
- Open Access
Direct Synthesis of Allylic Sulfones via Hydrosulfonylation of 1,3-Dienes with Sulfinic Acids
Catalyst- and additive-free reactions for synthesizing valuable organic compounds have garnered significant attention in the context of sustainable development. As crucial structural motifs, allylic sulfones find extensive applications in pharmaceutical development and organic synthesis. Despite remarkable advances in allylic sulfone construction, catalyst-free and additive-free methodologies remain an underexplored frontier. Herein, we present an environmentally benign and atom-economical approach for synthesizing allylic sulfones by reacting electron-rich aryl-1,3-dienes with sulfinic acids, achieving yields of 10–94%. This transformation proceeds under ambient air at room temperature, eliminating the need for catalysts or additives. The protocol demonstrates exceptional regio- and chemo-selectivity, streamlined operational simplicity, and excellent scalability potential. This methodology establishes a sustainable and cost-effective paradigm for allylic sulfone synthesis, aligning with green chemistry principles.
Open AccessDirect Synthesis of Allylic Sulfones via Hydrosulfonylation of 1,3-Dienes with Sulfinic Acids
Catalyst- and additive-free reactions for synthesizing valuable organic compounds have garnered significant attention in the context of sustainable development. As crucial structural motifs, allylic sulfones find extensive applications in pharmaceutical development and organic synthesis. Despite remarkable advances in allylic sulfone construction, catalyst-free and additive-free methodologies remain an underexplored frontier. Herein, we present an environmentally benign and atom-economical approach for synthesizing allylic sulfones by reacting electron-rich aryl-1,3-dienes with sulfinic acids, achieving yields of 10–94%. This transformation proceeds under ambient air at room temperature, eliminating the need for catalysts or additives. The protocol demonstrates exceptional regio- and chemo-selectivity, streamlined operational simplicity, and excellent scalability potential. This methodology establishes a sustainable and cost-effective paradigm for allylic sulfone synthesis, aligning with green chemistry principles.