Bridget Linders
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Bridget Linders has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
Anas Ani
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publicationArjun Singh
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publication- Benjamin S. Schuster
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publication Bruna Favetta
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publicationEmily G. Pinlac
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publication- Fleurie M. Kelley
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
1 shared publication
Latest Publications
- Top Cited PapersOpen Access
- 14 April 2025
- Published by Springer Nature in Nature Communications
- Vol. 16 (1) , 1-15
Controlled and orthogonal partitioning of large particles into biomolecular condensates
Partitioning of client molecules into biomolecular condensates is critical for regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning. Here, we ask whether large clients, such as macromolecular complexes and nanoparticles, can partition into condensates based on particle-condensate interactions. We seek to discover the fundamental biophysical principles that govern particle inclusion in or exclusion from condensates, using polymer nanoparticles surface-functionalized with biotin or oligonucleotides. Based on our experiments, coarse-grained molecular dynamics simulations, and theory, we conclude that arbitrarily large particles can controllably partition into condensates given sufficiently strong condensate-particle interactions. Remarkably, we also observe that beads with distinct surface chemistries partition orthogonally into immiscible condensates. These findings may provide insights into how various cellular processes are achieved based on partitioning of large clients into biomolecular condensates, and they offer design principles for drug delivery systems that selectively target disease-related condensates.
- 14 April 2025
- Published by Springer Nature in Nature Communications
- Vol. 16 (1) , 1-15
Top Cited PapersOpen AccessControlled and orthogonal partitioning of large particles into biomolecular condensates
Partitioning of client molecules into biomolecular condensates is critical for regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning. Here, we ask whether large clients, such as macromolecular complexes and nanoparticles, can partition into condensates based on particle-condensate interactions. We seek to discover the fundamental biophysical principles that govern particle inclusion in or exclusion from condensates, using polymer nanoparticles surface-functionalized with biotin or oligonucleotides. Based on our experiments, coarse-grained molecular dynamics simulations, and theory, we conclude that arbitrarily large particles can controllably partition into condensates given sufficiently strong condensate-particle interactions. Remarkably, we also observe that beads with distinct surface chemistries partition orthogonally into immiscible condensates. These findings may provide insights into how various cellular processes are achieved based on partitioning of large clients into biomolecular condensates, and they offer design principles for drug delivery systems that selectively target disease-related condensates.