Shourya Bodla

Rising global demand for waste-to-wealth generation has caught a lot of attention towards the biological remediation methods with human interventions to enhance capabilities to detoxify pollutants. This comprehensive book chapter aims to focus on the different biomanufacturing strategies and their roles in bioremediation processes. Metabolic engineering and synthetic biology leverage the production of enhanced biosystems. This chapter highlights various applications of biomanufacturing in the fields of pollution control and waste treatment. Engineered proteins and microbes are developed to degrade plastic waste and accompany a bioleaching process for extracting heavy metals from e-waste and also bioelectricity generation. Specific microbes are studied which can enhance the absorption of heavy metals such as Pseudomonas fluorescens and Bacillus subtilis. The circular economy strategies like reuse, reduce, and recycle, enhances economic, social, and environmental balance by increasing resource efficiency and providing long-term sustainability without any environmental effects.

Wound healing process is associated with multifaceted complications and is a functional way to advance the therapeutic process. Polymeric biomaterials exhibit structural mimicry with the extracellular matrix of the tissue to be regenerated and they also avoid chronic inflammation and immunological responses. Chitosan, a biopolymer demonstrates exceptional healing properties because of its biocompatibility, biodegradability, antimicrobial nature and affinity for biomolecules. Biomaterials consisting of chitosan along with herbal extracts could be ideal for wound healing. Click chemistry can provide one of the best ways to combine these bio-actives with chitosan. Advancing wound healing strategies with artificial intelligence /machine learning approaches can be employed further to boost the clinical efficacies of bioactive-loaded chitosan composite hydrogels. This review article investigates functionalized wound dressings with special emphasis on chitosan-based hydrogels, their effects on wound healing, and advanced approaches to increase hydrogel benefits by adding bioactive substances to form nanocomposites.