Eliska Cizkova
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Eliska Cizkova has a total of 19 co-authors. Here are the top co-authors by number of shared publications:
- Adolf Koudelka
Masaryk University 1 Department of Biology, Faculty of Medicine Brno
1 shared publication - Aleksandra Czyrek
Department of Biology, Faculty of Medicine, Masaryk University , Brno 62500
1 shared publication - Alexandru Nita
Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
1 shared publication - Antoni Wiedlocha
Institute for Cancer Research, Oslo University Hospital 6 Department of Molecular Cell Biology Oslo
1 shared publication - Bohumil Fafilek
Department of Biology, Faculty of Medicine, Masaryk University
1 shared publication - Canan Celiker
Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
1 shared publication
Latest Publications
- Open Access
- 22 April 2025
- Published by Rockefeller University Press in Journal of Cell Biology
- Vol. 224 (7)
FGFR2 residence in primary cilia is necessary for epithelial cell signaling
Primary cilium projects from cells to provide a communication platform with neighboring cells and the surrounding environment. This is ensured by the selective entry of membrane receptors and signaling molecules, producing fine-tuned and effective responses to the extracellular cues. In this study, we focused on one family of signaling molecules, the fibroblast growth factor receptors (FGFRs), their residence within cilia, and its role in FGFR signaling. We show that FGFR1 and FGFR2, but not FGFR3 and FGFR4, localize to primary cilia of the developing mouse tissues and in vitro cells. For FGFR2, we demonstrate that the ciliary residence is necessary for its signaling and expression of target morphogenic genes. We also show that the pathogenic FGFR2 variants have minimal cilium presence, which can be rescued for the p.P253R variant associated with the Apert syndrome by using the RLY-4008 kinase inhibitor. Finally, we determine the molecular regulators of FGFR2 trafficking to cilia, including IFT144, BBS1, and the conserved T429V430 motif within FGFR2.
- 22 April 2025
- Published by Rockefeller University Press in Journal of Cell Biology
- Vol. 224 (7)
Open AccessFGFR2 residence in primary cilia is necessary for epithelial cell signaling
Primary cilium projects from cells to provide a communication platform with neighboring cells and the surrounding environment. This is ensured by the selective entry of membrane receptors and signaling molecules, producing fine-tuned and effective responses to the extracellular cues. In this study, we focused on one family of signaling molecules, the fibroblast growth factor receptors (FGFRs), their residence within cilia, and its role in FGFR signaling. We show that FGFR1 and FGFR2, but not FGFR3 and FGFR4, localize to primary cilia of the developing mouse tissues and in vitro cells. For FGFR2, we demonstrate that the ciliary residence is necessary for its signaling and expression of target morphogenic genes. We also show that the pathogenic FGFR2 variants have minimal cilium presence, which can be rescued for the p.P253R variant associated with the Apert syndrome by using the RLY-4008 kinase inhibitor. Finally, we determine the molecular regulators of FGFR2 trafficking to cilia, including IFT144, BBS1, and the conserved T429V430 motif within FGFR2.