Marien Semprun
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Marien Semprun has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Carlos Silva Paredes
Universidad del Zulia, Facultad de Medicina, Departamento de Ciencias Fisiológicas, Maracaibo 4001, Venezuela
3 shared publications - Juan Lauretta
University of Zulia. Maracaibo, Venezuela. Postgraduate Chest Surgery
2 shared publications - Valmore Bermúdez
Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia
2 shared publications - Diego Rivera-Porras
Universidad de la Costa, Departamento de Productividad e Innovación, Barranquilla 080001, Atlántico, Colombia
1 shared publication Facultad de Medicina. Cátedra de Fisiología Humana Universidad del Zulia
1 shared publicationJennifer Rojas
Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo, Venezuela
1 shared publication
Latest Publications
- Open Access
- 14 September 2025
- Published by Saber UCV in Gaceta Médica de Caracas
- Vol. 133 (3) , 889-909
From clouds to clarity: Understanding the real consequences of e-cigarettes and EVALI
Electronic cigarettes are devices that heat liquid into aerosols for inhalation. According to the CDC and FDA, a 2022 survey found that 14.1% of high school students and 3.3% of college students in the U.S. used these devices, totaling 2.55 million young users. This growing trend gained serious attention in 2019 with the emergence of EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury), predominantly affecting teenagers and young adults. EVALI presents with acute respiratory symptoms, often requiring hospitalization, and by February 2020, it had caused approximately 2800 hospitalizations and 68 deaths. Although vitamin E acetate (VEA) was strongly implicated, other factors (including solvents, psychoactive substances, heavy metals, and flavorings) are under investigation. Compounding the issue, the COVID-19 pandemic has posed diagnostic challenges due to symptom overlap. The long-term health effects of electronic cigarette use remain uncertain, but research has linked it to chronic respiratory diseases like COPD, cancer, and systemic and cardiovascular diseases.
- 14 September 2025
- Published by Saber UCV in Gaceta Médica de Caracas
- Vol. 133 (3) , 889-909
Open AccessFrom clouds to clarity: Understanding the real consequences of e-cigarettes and EVALI
Electronic cigarettes are devices that heat liquid into aerosols for inhalation. According to the CDC and FDA, a 2022 survey found that 14.1% of high school students and 3.3% of college students in the U.S. used these devices, totaling 2.55 million young users. This growing trend gained serious attention in 2019 with the emergence of EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury), predominantly affecting teenagers and young adults. EVALI presents with acute respiratory symptoms, often requiring hospitalization, and by February 2020, it had caused approximately 2800 hospitalizations and 68 deaths. Although vitamin E acetate (VEA) was strongly implicated, other factors (including solvents, psychoactive substances, heavy metals, and flavorings) are under investigation. Compounding the issue, the COVID-19 pandemic has posed diagnostic challenges due to symptom overlap. The long-term health effects of electronic cigarette use remain uncertain, but research has linked it to chronic respiratory diseases like COPD, cancer, and systemic and cardiovascular diseases.
- Open Access
- 23 April 2025
- Published by MDPI AG in Journal of Personalized Medicine
- Vol. 15 (5) , 162
Primary Pleural Lymphoma in an Immune-Competent Patient: A Diagnostic and Therapeutic Challenge
Background: Primary pleural lymphoma is a rare disease posing diagnostic and therapeutic challenges. Case presentation: We present a 65-year-old woman with dyspnoea, cough, and asthenia, with no significant past medical history. Chest X-ray and computed tomography showed extensive right pleural effusion. Video-assisted thoracoscopy demonstrated multiple pleural nodules, while pleural fluid analysis revealed a lymphocytic exudate, and finally, a primary pleural lymphoma diagnosis was confirmed by immunohistochemistry analysis in pleural nodules biopsy. Discussion: In this regard, eight cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and rituximab were indicated, and after one year of follow-up, complete clinical and radiological remission was observed. Conlusions: We conclude that video-assisted thoracoscopy with an appropriate histopathological examination remains the gold standard for diagnosis, while R-CHOP chemotherapy plus rituximab may represent a highly effective therapeutic choice.
- 23 April 2025
- Published by MDPI AG in Journal of Personalized Medicine
- Vol. 15 (5) , 162
Open AccessPrimary Pleural Lymphoma in an Immune-Competent Patient: A Diagnostic and Therapeutic Challenge
Background: Primary pleural lymphoma is a rare disease posing diagnostic and therapeutic challenges. Case presentation: We present a 65-year-old woman with dyspnoea, cough, and asthenia, with no significant past medical history. Chest X-ray and computed tomography showed extensive right pleural effusion. Video-assisted thoracoscopy demonstrated multiple pleural nodules, while pleural fluid analysis revealed a lymphocytic exudate, and finally, a primary pleural lymphoma diagnosis was confirmed by immunohistochemistry analysis in pleural nodules biopsy. Discussion: In this regard, eight cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and rituximab were indicated, and after one year of follow-up, complete clinical and radiological remission was observed. Conlusions: We conclude that video-assisted thoracoscopy with an appropriate histopathological examination remains the gold standard for diagnosis, while R-CHOP chemotherapy plus rituximab may represent a highly effective therapeutic choice.
- Open Access
- 16 September 2023
- Published by Saber UCV in Gaceta Médica de Caracas
- Vol. 131 (3)
Estudio piloto de la prevalencia del consumo de cigarrillos en adultos jóvenes en Maracaibo, Venezuela
Introducción: El tabaquismo se asocia con el desarrollo de enfermedades pulmonares crónicas, enfermedades cardiovasculares y distintos tipos de canceres. Los cigarrillos electrónicos son productos que se han considerados como una alternativa segura a los cigarrillos convencionales y, promocionados como menos dañinos. Estos dispositivos se han asociado a enfermedades pulmonares graves llamado EVALI. Objetivo: determinar la prevalencia del consumo de cigarrillos electrónicos y convencionales en la población de adultos jóvenes. Materiales y métodos: Se realizó un estudio piloto de tipo no experimental, transversal y descriptivo en 225 individuos seleccionados mediante un muestreo no probabilístico, de ambos sexos con edades comprendidas entre los 17 y 25 años de la ciudad de Maracaibo, Venezuela.
- 16 September 2023
- Published by Saber UCV in Gaceta Médica de Caracas
- Vol. 131 (3)
Open AccessEstudio piloto de la prevalencia del consumo de cigarrillos en adultos jóvenes en Maracaibo, Venezuela
Introducción: El tabaquismo se asocia con el desarrollo de enfermedades pulmonares crónicas, enfermedades cardiovasculares y distintos tipos de canceres. Los cigarrillos electrónicos son productos que se han considerados como una alternativa segura a los cigarrillos convencionales y, promocionados como menos dañinos. Estos dispositivos se han asociado a enfermedades pulmonares graves llamado EVALI. Objetivo: determinar la prevalencia del consumo de cigarrillos electrónicos y convencionales en la población de adultos jóvenes. Materiales y métodos: Se realizó un estudio piloto de tipo no experimental, transversal y descriptivo en 225 individuos seleccionados mediante un muestreo no probabilístico, de ambos sexos con edades comprendidas entre los 17 y 25 años de la ciudad de Maracaibo, Venezuela.