Pretty Falena Atmanda Kambira

Mitragyna speciosa, commonly referred to as kratom, is known for its active compound, mitragynine, which is classified as a new psychoactive substance. The availability of mitragynine standards remains a challenge, highlighting the need for effective and efficient methods for isolating this compound from kratom. This study aimed to computationally design a molecularly imprinted polymer (MIP) for the selective isolation of mitragynine. Computational studies were conducted using the B3LYP def2TZVP method with DFT-D4 dispersion, and the results were verified by a laboratory experiment and a molecular dynamics study. The study revealed that methacrylic acid was the optimal monomer for MIP interactions in methanol. Laboratory experiments, employing the association constant and Job plot methods, confirmed that methanol was the ideal solvent for the pre-polymerization complex, with an equilibrium template-to-monomer ratio of 1:3. Radial distribution function analysis from molecular dynamics simulations further supported that the 1:3 template-to-monomer ratio was optimal, aligning with experimental findings. This study’s findings suggest that computational analysis may be employed for the rational design of improved MIPs and for further laboratory investigation into the selective isolation of mitragynine from plants.

Sleep disorders are a health problem that is often experienced by various population groups, especially the elderly, infants, as well as pregnant and post-natal women. Aromatherapy with essential oils is one of the non-pharmacological approaches that is increasingly used because it is considered safer and more acceptable. Objective: This study aims to systematically review studies in Indonesia that evaluate the effectiveness of aromatherapy using essential oils on sleep quality. Method: The literature search was conducted using the Google Scholar search engine with the help of the Publish or Perish application. Keywords related to "aromatherapy", "essential oils", and "sleep disorders" are used to find suitable articles. Inclusion criteria include studies with essential oil interventions through inhalation or massage involving the population in Indonesia and containing sleep quality data as an output. Results: Twelve articles met the inclusion criteria. Most studies used lavender oil and showed a significant improvement in sleep quality. Some studies have also evaluated essential oils from local plants such as sandalwood, lynae, jasmine, and rose, which show positive results although their numbers are still limited. The duration of the intervention varied between one day and two months. The route of administration is generally through inhalation and massage, with no reports of serious side effects. Conclusion: Aromatherapy with essential oils, including from the local flora of Indonesia, has the potential to be an effective and safe non-pharmacological alternative to improve sleep quality. Further research is needed to strengthen scientific evidence, determine the optimal duration and dosage, and develop the economic potential of local resource-based essential oils.

Kegiatan pengabdian masyarakat berupa workshop budidaya dan pemanfaatan jeruk nipis sebagai Tanaman Obat Keluarga (TOGA) telah berhasil meningkatkan pengetahuan anggota Kelompok Wanita Tani (KWT) di Desa Wisata Wates Jaya, Bogor. Desa ini, yang terletak di lereng Gunung Pangrango, memiliki potensi pertanian yang belum dimanfaatkan secara optimal. Jeruk nipis dipilih sebagai fokus kegiatan karena manfaatnya bagi kesehatan, potensi ekonominya, dan kemudahan budidayanya di lahan terbatas. Kegiatan ini melibatkan 21 anggota KWT dan mencakup materi komprehensif tentang manfaat kesehatan, aplikasi industri, potensi ekonomi, dan teknik budidaya jeruk nipis, termasuk pembibitan, penanaman, dan perawatan tanaman. Hasil evaluasi menunjukkan peningkatan pengetahuan peserta, terutama terkait teknik budidaya. Pemberian bibit jeruk nipis diharapkan dapat menjadi stimulus bagi anggota KWT untuk memulai budidaya secara mandiri, meningkatkan pendapatan ekonomi, dan memperbaiki kesehatan keluarga. Dukungan berkelanjutan, pelatihan lanjutan, dan pengembangan produk olahan jeruk nipis menjadi rekomendasi untuk keberlanjutan program ini, sehingga dapat memberikan dampak positif yang lebih luas bagi masyarakat desa.

Background: Medication adherence among patients with chronic diseases remains challenging for healthcare professionals. The large number and types of drugs that must be taken in the long term and the lack of knowledge related to drugs and diseases are factors that affect patient compliance. Telepharmacy is expected to improve patient medication adherence by providing easy access to consult with pharmacists. Objective: To assess the effect of telepharmacy on chronic patient medication adherence. Methods: This study had a cross-sectional study design, and the study population was Lifepack application users. The data was collected through an online questionnaire distributed through the Lifepack platform. The adherence was evaluated using the Morisky Medication Adherence Scale, and the association of telepharmacy and patient medication adherence was examined using the chi-square independence test with significance at p < 0.05. Results: In a study comprising of 94 respondents, a proportional ratio of respondents who used and did not use telepharmacy services was observed (45.75% and 54.25%, respectively). Analysis using the chi-square statistic (χ²) demonstrated a significant association between telepharmacy and patient adherence (χ² = 64.745, df = 1, p < 0.001). Furthermore, the odds ratio (OR) revealed a substantial difference in adherence, with an OR of 122.67 (95% CI [27.58, 545.66]). Conclusion: Telepharmacy has a significant impact on medication adherence in chronic patients.

Kegiatan promosi kesehatan kulit pada siswa SMA Methodist, Jakarta Utara yang dilaksanakan pada tanggal 20 Juli 2023 berhasil meningkatkan pengetahuan siswa tentang kesehatan kulit. Hal ini terlihat dari peningkatan nilai rata-rata pengetahuan siswa dari 4,42 menjadi 9,49. Kegiatan ini juga mendapatkan umpan balik yang sangat baik dari peserta. Secara keseluruhan, 95,16% peserta menyatakan puas dengan kegiatan ini. Kegiatan ini menggunakan metode ceramah, workshop, dan pemberian flyer. Ceramah disampaikan oleh dosen farmasi dari Universitas Katolik Indonesia Atma Jaya, sedangkan workshop pembuatan masker peel-off dipandu oleh mahasiswa/i program studi Farmasi, FKIK Universitas Katolik Indonesia Atma Jaya. Flyer kesehatan kulit yang disusun secara sistematis, singkat, dan padat juga diberikan kepada peserta. Selain itu, kegiatan ini juga menghasilkan satu series video edukasi dengan topik ‘Perawatan Kulit Wajah’ yang terdiri dari tiga video pendek berdurasi tidak lebih dari 4 menit. Ketiga video ini diunggah di platform media sosial Instagram agar dapat menjangkau masyarakat yang lebih luas tidak hanya peserta seminar dan workshop. Kegiatan promosi kesehatan kulit ini diharapkan dapat meningkatkan kesadaran masyarakat, khususnya remaja, tentang pentingnya perawatan kulit yang aman dan sesuai dengan kebutuhan kulit.

Pneumonia, a severe respiratory disease, can have deadly consequences. Increased air pollution in Jakarta can increase the risk of respiratory tract diseases, including Pneumonia. The risk of Pneumonia infection in adults can be reduced by vaccination. The Pharmacy Department of the Atma Jaya Catholic University of Indonesia held an in-depth seminar on Pneumonia and vaccination to provide information and invite all people to understand the urgency of vaccination. Educational activities are conducted as online seminars using a video conferencing platform. Two speakers gave interactively educational information about Pneumonia and vaccination, and more than 60 people attended the seminar. Demographic data on participants shows that the gender of most participants was female, the age of most participants was 26-45 years old, and the education level of most participants was university level. Of the participants who attended, as many as 63.7% had never been vaccinated against Pneumonia, and 68.1% were willing to be vaccinated against Pneumonia. In conclusion, this seminar successfully increased the knowledge and awareness of the public about Pneumonia and vaccination.

Introduction: Indonesia is a tropical country with high temperatures and humidity. Poor personal hygiene can trigger bacteria to grow and multiply. According to research, bacteria that are usually found in skin and hair including Staphylococcus aureus (37%), followed by Escherichia coli (17%). Use of antibacterial hairspray is expected to inhibit the growth of pathogenic bacteria on the surface of the scalp and hair. Using natural ingredients, i.e., cherry (Muntingia calabura L.) leaves, in the form of antibacterial hairspray preparations, is expected not to irritate the scalp, be more eco-friendly, and the raw materials are easily obtained. Methods: The preparation of cherry (Muntingia calabura L.) leaves extract was carried out by maceration method with 70% ethanol (simplisia : solvent = 1:10). Furthermore, the extract was then evaluated for phytochemical content, formulation optimization, and antibacterial activity. Afterward, formulation and preparation, and lastly, its evaluation in the form of an organoleptic test, pH test, viscosity test, homogeneity test, spreadability test, adhesion test, and product stability test. Results: The results of phytochemical screening of flavonoid compounds and tannins from cherry (Muntingia calabura L.) leaves extract resulted in a positive reaction. The minimum inhibitory level of cherry (Muntingia calabura L.) leaves extract against Staphylococcus aureus and Escherichia coli bacteria was 40 mg/ml. Cherry (Muntingia calabura L.) leaves extract was then formulated into hairspray dosage forms with different concentrations of extract in Formula A (0.1%), Formula B (0.3%), and Formula C (0.5%). Conclusions: The hairspray formula that had the best stability after passing the freeze-thaw cycling test and physical evaluation of the preparation during storage for 28 days was Formula C. The parameters of the observed hairspray were organoleptic, pH, homogeneity, viscosity, spreadability, and adhesion. Keywords: Hairspray - Cherry Leaves – Stability - Antibacterial

Eucalyptus sp. is a family member of Myrtaceae, and its oil has been used commercially in the food industry, cosmetics, and pharmaceutical preparation. The fame of Eucalyptus oil rose during the COVID-19 pandemic because several claims have antiviral activity against the coronavirus. Nevertheless, this claim is not scientifically proven and could lead to misinformation among the public. Eucalyptus oil is known to have antibacterial activity against gram-positive and gram-negative bacteria. However, to what extent its effectiveness is has yet to be discovered. Therefore, this study aims to assess eucalyptus oil's antibacterial and antiviral activity using the Cochrane systematic review. The studies included in the systematic review were retrieved from the PubMed and Science Direct databases. The search query was ("Eucalyptus oil" OR "Eucalyptol") AND ("Antibacterial" OR "Antiviral" OR "MIC"). There are 114 articles identified from the search strategies, and additional 4 articles were found from citation research. After the removal of duplication, 83 articles remained. However, 61 articles were excluded because they did not report the antimicrobial activity of eucalyptus oil. Twenty-two articles were screened for full-text, and 61 were excluded because it does not meet the inclusion criteria. Finally, 16 articles were included in this systematic review. Eucalyptus oil has an antibacterial and antiviral activity that depends on its chemical composition and microbial strains. Therefore, make it a prominent candidate as an antimicrobial and disinfectant compound. However, future clinical study about its mechanism of action is needed.