André Maurício Passos Liber
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
André Maurício Passos Liber has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Cristiane Damas Gil
Biosciences Graduate Program, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil; Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
1 shared publication - Diego Dias dos Santos
Department of Morphology and Genetics Federal University of São Paulo São Paulo São Paulo Brazil
1 shared publication - Dora Fix Ventura
Department of Experimental Psychology, Psychology Institute University of São Paulo São Paulo Brazil
1 shared publication - Francisco Manuel Moreno-Carmona
Department of Experimental Psychology, Institute of Psychology, Universidade de São Paulo (USP), São Paulo, SP 05508-030, Brazil
1 shared publication - Luiz Philipe de Souza Ferreira
Structural and Functional Biology Graduate Program, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil
1 shared publication - Marcelo Fernandes Costa
Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brazil
1 shared publication
Latest Publications
- Open Access
Electroretinographic and Morphological Characterization of the Retina of Annexin A1 Knockout Mice
Background/Objectives: The annexin A1 (AnxA1) protein has proven important in ocular disease homeostasis and holds great therapeutic promise. However, its role in the context of the healthy retina remains unknown. Therefore, this study used electroretinography (ERG) to investigate the role of endogenous AnxA1 in the retinal function of wild-type (WT) and AnxA1 knockout mice (AnxA1−/−). Methods: An extensive repertoire of full-field ERG was applied to AnxA1−/− and WT mice to examine retinal physiology. Morphometric analyses of the retina were conducted. Results: Our results revealed significant differences in the implicit time of a-wave and b-wave between the WT and AnxA1−/− groups under scotopic conditions. The negative and positive amplitude components of mesopic ON responses were higher in the AnxA1-/- group than in the WT group. In contrast, the implicit time of mesopic ON responses were significantly higher in the WT group than in the AnxA1-/- WT group. However, in photopic OFF responses, only the implicit time was significantly longer in the WT group than in the AnxA1−/− group. In the histomorphometric analysis, the retina of AnxA1−/− mice shows increased thickness. Conclusions: The absence of AnxA1 alters retinal morphology and physiology.
Open AccessElectroretinographic and Morphological Characterization of the Retina of Annexin A1 Knockout Mice
Background/Objectives: The annexin A1 (AnxA1) protein has proven important in ocular disease homeostasis and holds great therapeutic promise. However, its role in the context of the healthy retina remains unknown. Therefore, this study used electroretinography (ERG) to investigate the role of endogenous AnxA1 in the retinal function of wild-type (WT) and AnxA1 knockout mice (AnxA1−/−). Methods: An extensive repertoire of full-field ERG was applied to AnxA1−/− and WT mice to examine retinal physiology. Morphometric analyses of the retina were conducted. Results: Our results revealed significant differences in the implicit time of a-wave and b-wave between the WT and AnxA1−/− groups under scotopic conditions. The negative and positive amplitude components of mesopic ON responses were higher in the AnxA1-/- group than in the WT group. In contrast, the implicit time of mesopic ON responses were significantly higher in the WT group than in the AnxA1-/- WT group. However, in photopic OFF responses, only the implicit time was significantly longer in the WT group than in the AnxA1−/− group. In the histomorphometric analysis, the retina of AnxA1−/− mice shows increased thickness. Conclusions: The absence of AnxA1 alters retinal morphology and physiology.